妄想（精神病性）和非妄想性抑郁症患者中生物胺代谢产物与症状学的关联。

Association of biogenic amine metabolites with symptomatology in delusional (psychotic) and nondelusional depressed patients.

Lykouras L, Markianos M, Hatzimanolis J, Malliaras D, Stefanis C

Athens University Medical School, Psychiatric Clinic, Greece.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):877-87. doi: 10.1016/0278-5846(95)00117-e.

Abstract

The levels of the main norepinephrine, serotonin, and dopamine metabolite excretion in the urine, MHPG, 5HIAA and HVA respectively, were measured in 84 patients with major depressive disorder, 34 delusional (psychotic) and 50 nondelusional (DSM-III-R criteria). 2. Associations with the 17 items of the HDRS were evaluated using the multiple regression analysis model. In the delusional group, MHPG excretion was positively related to the scores in the items of depressed mood (p = 0.04), middle insomnia (p = 0.008) and genital symptoms (p = 0.001). 5HIAA excretion was negatively associated with late insomnia (p = 0.02), work and interests (p = 0.001) and genital symptoms (p = 0.007). HVA was positively related to agitation (p = 0.043). In the nondelusional group the only association found was between agitation and HVA excretion (p = 0.03).

摘要

分别测定了84例重度抑郁症患者尿液中主要去甲肾上腺素、血清素和多巴胺代谢物的排泄水平，即3-甲氧基-4-羟基苯乙二醇（MHPG）、5-羟吲哚乙酸（5HIAA）和高香草酸（HVA），其中34例为妄想型（精神病性），50例为非妄想型（符合《精神疾病诊断与统计手册》第三版修订版标准）。2. 使用多元回归分析模型评估了与汉密尔顿抑郁量表（HDRS）17项内容的相关性。在妄想型组中，MHPG排泄与情绪低落项目得分呈正相关（p = 0.04），与中度失眠项目得分呈正相关（p = 0.008），与生殖器症状项目得分呈正相关（p = 0.001）。5HIAA排泄与晚期失眠项目得分呈负相关（p = 0.02），与工作和兴趣项目得分呈负相关（p = 0.001），与生殖器症状项目得分呈负相关（p = 0.007）。HVA与激越呈正相关（p = 0.043）。在非妄想型组中，唯一发现的关联是激越与HVA排泄之间的关联（p = 0.03）。