Rudin C, Camli C, Schnüriger H, Biedermann K, Lauper U, Kind C
Universitäts-Kinderklinik Basel.
Schweiz Med Wochenschr. 1995 Dec 2;125(48):2322-9.
Since 1990 216 HIV-infected pregnant women have been enrolled in an ongoing nationwide study named "HIV and Pregnancy" financed by the Swiss Federal Office of Health (No. 90-7007 and 93-7131). Of a total of 228 recorded pregnancies 154 continued to parturition. Until now it has been definitively established whether or not 89 offsprings have been infected with HIV by their mothers. According to clinical and immunological findings most of the pregnant women are still in early, stable stages of HIV-infection (stages II and III of the CDC classification system in 94% of the subjects; mean CD4-cell count around 600/microliters). HIV infection was the consequence of an intravenous substance abuse in two thirds of the women. Detailed interviews revealed an alarming negligence with regard to compliance with safer sex recommendations and contraception. Advisory services of specialized AIDS information centers have very rarely been called on. In our group, the vertical transmission rate shows a statistically significant correlation with low maternal anti-HIV-p24 antibody titers, high serum neopterin- and IgA-concentrations, and also with the use of forceps and vacuum in vaginal delivery. Maternal substance abuse but not HIV infection itself resulted in an incidence of preterm deliveries roughly twice as high as in the normal Swiss population.
自1990年以来，216名感染HIV的孕妇参与了一项由瑞士联邦卫生局资助的正在进行的全国性研究“HIV与妊娠”（编号90 - 7007和93 - 7131）。在总共记录的228次妊娠中，154例持续至分娩。到目前为止，已明确89名婴儿是否被其母亲感染HIV。根据临床和免疫学检查结果，大多数孕妇仍处于HIV感染的早期、稳定阶段（94%的受试者为疾病控制中心分类系统的II期和III期；平均CD4细胞计数约为600/微升）。三分之二的女性因静脉注射药物滥用而感染HIV。详细访谈显示，在遵守安全性行为建议和避孕方面存在令人担忧的疏忽。很少有人向专门的艾滋病信息中心咨询服务求助。在我们的研究组中，垂直传播率与母亲低抗HIV - p24抗体滴度、高血清新蝶呤和IgA浓度以及阴道分娩时使用产钳和真空吸引显著相关。母亲药物滥用而非HIV感染本身导致早产发生率大约是瑞士正常人群的两倍。
