Rhomberg W, Böhler F, Vith A, Breitfellner G
Abteilung für Radio-Onkologie, Landeskrankenhaus Feldkirch, Osterreich.
Schweiz Med Wochenschr. 1995 Dec 2;125(48):2330-7.
In a 68-year-old man with a painful syndrome of the lower extremities which began at the age of 64 years, workup revealed a generalized osteopathy with sclerosis of the axial skeleton and osteopenia at the extremities associated with pathologic fractures. The occupational history showed exposure to several synthetics such as vinyl chloride, polyethylene, delrine and polyamides over 30 years. However, a presumptive connection between the skeletal disorder and the occupational exposure could not initially be substantiated. In a later analysis of the bone biopsies from 1991, a significant increase of fluorine in the tibia and fibula of the patient was detected and thus the diagnosis of industrial fluorosis established. The fluorine presumably originated from the workup of polytetrafluorethylene plates. A detailed analysis of the workplace is ongoing. The fluorosis may obviously appear as a variable skeletal disease. The clinical picture of fluorosis is incompletely described in most of the German textbooks. It calls for an extended description of the X-ray findings associated with fluorosis and a new definition of the disease.
一名68岁男性，64岁时开始出现下肢疼痛综合征，检查发现全身性骨病，中轴骨骼硬化，四肢骨质减少并伴有病理性骨折。职业史显示，他在30多年间接触过多种合成材料，如氯乙烯、聚乙烯、德尔林和聚酰胺。然而，最初无法证实骨骼疾病与职业暴露之间存在推定联系。在对1991年的骨活检进行后续分析时，检测到患者胫骨和腓骨中的氟含量显著增加，从而确诊为工业性氟中毒。氟可能源自聚四氟乙烯板的加工过程。目前正在对工作场所进行详细分析。氟中毒显然可能表现为一种可变的骨骼疾病。大多数德国教科书中对氟中毒的临床表现描述并不完整。需要对与氟中毒相关的X线表现进行更详细的描述，并对该疾病进行重新定义。
