• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

左氧氟沙星单独及与利福霉素类似物联合对麻风分枝杆菌的体外活性。

In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.

作者信息

Dhople A M, Ibanez M A

机构信息

Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988, USA.

出版信息

Antimicrob Agents Chemother. 1995 Sep;39(9):2116-9. doi: 10.1128/AAC.39.9.2116.

DOI:10.1128/AAC.39.9.2116
PMID:8540726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162891/
Abstract

The in vitro susceptibility of Mycobacterium leprae to levofloxacin was studied by using two biochemical parameters to measure the metabolic activity of the organism. Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 microgram/ml. When combined with one of the three rifamycin analogs, synergism was obtained with KRM-1648 and rifabutin but not with rifampin.

摘要

通过使用两个生化参数来测量麻风分枝杆菌的代谢活性，对其进行了体外左氧氟沙星敏感性研究。左氧氟沙星的杀菌活性始终比氧氟沙星高两倍，最低抑菌浓度为0.75微克/毫升。当与三种利福霉素类似物之一联合使用时，与KRM - 1648和利福布汀获得了协同作用，但与利福平没有协同作用。

相似文献

1
In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.左氧氟沙星单独及与利福霉素类似物联合对麻风分枝杆菌的体外活性。
Antimicrob Agents Chemother. 1995 Sep;39(9):2116-9. doi: 10.1128/AAC.39.9.2116.
2
In-vitro activity of sitafloxacin (DU-6859a), either singly or in combination with rifampin analogs, against Mycobacterium leprae.司他夫沙星（DU-6859a）单独或与利福平类似物联合使用时对麻风分枝杆菌的体外活性。
J Infect Chemother. 2003 Mar;9(1):12-5. doi: 10.1007/s10156-002-0212-8.
3
The in-vitro activities of novel benzoxazinorifamycins against Mycobacterium leprae.新型苯并恶嗪诺利霉素对麻风分枝杆菌的体外活性。
J Antimicrob Chemother. 1995 Apr;35(4):463-71. doi: 10.1093/jac/35.4.463.
4
In vitro synergistic activity between ofloxacin and ansamycins against Mycobacterium leprae.氧氟沙星与安莎霉素对麻风分枝杆菌的体外协同活性。
Arzneimittelforschung. 1993 Mar;43(3):384-6.
5
In vitro activity of a new rifamycin derivative against Mycobacterium leprae.一种新型利福霉素衍生物对麻风分枝杆菌的体外活性
Arzneimittelforschung. 1996 Feb;46(2):210-2.
6
In-vitro activity of three new fluoroquinolones and synergy with ansamycins against Mycobacterium leprae.三种新型氟喹诺酮类药物的体外活性及其与安莎霉素对麻风分枝杆菌的协同作用。
J Antimicrob Chemother. 1993 Sep;32(3):445-51. doi: 10.1093/jac/32.3.445.
7
Inhibitory and bactericidal activities of levofloxacin, ofloxacin, erythromycin, and rifampin used singly and in combination against Legionella pneumophila.左氧氟沙星、氧氟沙星、红霉素和利福平单独及联合使用对嗜肺军团菌的抑制和杀菌活性。
Antimicrob Agents Chemother. 1995 Aug;39(8):1661-6. doi: 10.1128/AAC.39.8.1661.
8
In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.
Int J Antimicrob Agents. 2001 Jan;17(1):57-61. doi: 10.1016/s0924-8579(00)00306-x.
9
[Tympanostomy tube otorrhea: microbiological epidemiology, pathogen susceptibility to local antibiotics and bactericidal power of the rifamycin-olfloxacin combination].[鼓膜置管耳漏：微生物流行病学、病原体对局部抗生素的敏感性及利福霉素-氧氟沙星组合的杀菌能力]
Ann Otolaryngol Chir Cervicofac. 2001 Oct;118(5):278-82.
10
In vivo susceptibility of Mycobacterium leprae to sitafloxacin (DU-6859a), either singly or in combination with rifampicin analogues.麻风分枝杆菌对司帕沙星（DU-6859a）单独或与利福平类似物联合使用时的体内敏感性。
Int J Antimicrob Agents. 2003 Mar;21(3):251-5. doi: 10.1016/s0924-8579(02)00351-5.

引用本文的文献

1
Adverse reactions induced by MDT/WHO (Rifampicin+Clofazimine+Dapsone) and ROM (Rifampicin+Ofloxacin+Minocycline) regimens used in the treatment of leprosy: a cohort study in a National Reference Center in Brazil.在巴西一家国家参考中心进行的队列研究：用于治疗麻风病的MDT/WHO（利福平+氯法齐明+氨苯砜）和ROM（利福平+氧氟沙星+米诺环素）方案引起的不良反应
Front Pharmacol. 2024 Mar 7;15:1346169. doi: 10.3389/fphar.2024.1346169. eCollection 2024.
2
Approach to the diagnosis and treatment of non-tuberculous mycobacterial disease.非结核分枝杆菌病的诊断与治疗方法
J Clin Tuberc Other Mycobact Dis. 2021 May 8;24:100244. doi: 10.1016/j.jctube.2021.100244. eCollection 2021 Aug.
3
Tuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.结核病治疗揭示麻风病：耐多药结核病与麻风病合并感染的管理
Public Health Action. 2019 Sep 21;9(Suppl 1):S83-S85. doi: 10.5588/pha.18.0104.
4
In vitro activities of levofloxacin used alone and in combination with first- and second-line antituberculous drugs against Mycobacterium tuberculosis.左氧氟沙星单独及与一线和二线抗结核药物联合使用对结核分枝杆菌的体外活性。
Antimicrob Agents Chemother. 1996 Jul;40(7):1610-6. doi: 10.1128/AAC.40.7.1610.

本文引用的文献

1
Therapeutic efficacy of some new quinolones and a combination of ofloxacin with rifampin against Mycobacterium leprae infection induced in athymic nude mice.某些新型喹诺酮类药物以及氧氟沙星与利福平联合用药对无胸腺裸鼠诱发的麻风分枝杆菌感染的治疗效果。
Int J Lepr Other Mycobact Dis. 1993 Jun;61(2):250-4.
2
In vitro synergistic activity between ofloxacin and ansamycins against Mycobacterium leprae.氧氟沙星与安莎霉素对麻风分枝杆菌的体外协同活性。
Arzneimittelforschung. 1993 Mar;43(3):384-6.
3
Inhibitory and bactericidal activities of levofloxacin against Mycobacterium tuberculosis in vitro and in human macrophages.左氧氟沙星对结核分枝杆菌的体外及在人巨噬细胞中的抑制和杀菌活性。
Antimicrob Agents Chemother. 1994 May;38(5):1161-4. doi: 10.1128/AAC.38.5.1161.
4
In vivo susceptibility of Mycobacterium leprae to ofloxacin either singly or in combination with rifampicin and rifabutin. Anti-leprosy activity of ofloxacin and ansamycins in mice.
Arzneimittelforschung. 1994 Apr;44(4):563-5.
5
Elimination of leprosy as a public health problem.
Indian J Lepr. 1994 Jan-Mar;66(1):1-10.
6
The in-vitro activities of novel benzoxazinorifamycins against Mycobacterium leprae.新型苯并恶嗪诺利霉素对麻风分枝杆菌的体外活性。
J Antimicrob Chemother. 1995 Apr;35(4):463-71. doi: 10.1093/jac/35.4.463.
7
Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.具有抗假单胞菌活性的氨基糖苷类药物与头孢菌素之间的协同作用：相互作用指数和杀菌曲线法
Antimicrob Agents Chemother. 1982 Nov;22(5):743-52. doi: 10.1128/AAC.22.5.743.
8
Evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria.用于分枝杆菌快速药敏试验的生物发光测定法的评估
Eur J Clin Microbiol. 1985 Dec;4(6):556-61. doi: 10.1007/BF02013394.
9
In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280).新型抗菌物质氧氟沙星（DL8280）的体外抗结核活性
Am Rev Respir Dis. 1985 Mar;131(3):348-51. doi: 10.1164/arrd.1985.131.3.348.
10
Bacteriostatic and bactericidal activity of ciprofloxacin and ofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.环丙沙星和氧氟沙星对结核分枝杆菌及鸟分枝杆菌复合群的抑菌和杀菌活性
Tubercle. 1987 Dec;68(4):267-76. doi: 10.1016/0041-3879(87)90067-5.