左氧氟沙星单独及与利福霉素类似物联合对麻风分枝杆菌的体外活性。
In vitro activity of levofloxacin, singly and in combination with rifamycin analogs, against Mycobacterium leprae.
作者信息
Dhople A M, Ibanez M A
机构信息
Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988, USA.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):2116-9. doi: 10.1128/AAC.39.9.2116.
Abstract
The in vitro susceptibility of Mycobacterium leprae to levofloxacin was studied by using two biochemical parameters to measure the metabolic activity of the organism. Levofloxacin consistently exhibited twofold greater bactericidal activity than ofloxacin, with the MIC being 0.75 microgram/ml. When combined with one of the three rifamycin analogs, synergism was obtained with KRM-1648 and rifabutin but not with rifampin.
摘要
通过使用两个生化参数来测量麻风分枝杆菌的代谢活性，对其进行了体外左氧氟沙星敏感性研究。左氧氟沙星的杀菌活性始终比氧氟沙星高两倍，最低抑菌浓度为0.75微克/毫升。当与三种利福霉素类似物之一联合使用时，与KRM - 1648和利福布汀获得了协同作用，但与利福平没有协同作用。
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