左氧氟沙星对结核分枝杆菌的体外及在人巨噬细胞中的抑制和杀菌活性。
Inhibitory and bactericidal activities of levofloxacin against Mycobacterium tuberculosis in vitro and in human macrophages.
作者信息
Mor N, Vanderkolk J, Heifets L
机构信息
National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80220.
出版信息
Antimicrob Agents Chemother. 1994 May;38(5):1161-4. doi: 10.1128/AAC.38.5.1161.
Abstract
Levofloxacin exhibited twofold greater inhibitory and bactericidal activities than ofloxacin against either extracellular or intracellular tubercle bacilli. The activities of both drugs against extracellular and intracellular bacteria were about the same, despite the accumulation of the drugs in macrophages at a level four- to fivefold greater than that in the extracellular medium. The activities of both drugs against intracellular bacteria were largely associated with the short, 2-h pulsed exposures of the infected macrophages to the concentrations which correspond to those attainable in blood during the period of the maximum concentration of drug in serum.
摘要
左氧氟沙星对细胞外或细胞内结核杆菌的抑制和杀菌活性比对氧氟沙星高两倍。尽管这两种药物在巨噬细胞中的蓄积水平比细胞外培养基中的高四至五倍，但它们对细胞外和细胞内细菌的活性大致相同。这两种药物对细胞内细菌的活性很大程度上与受感染巨噬细胞短时间（2小时）脉冲暴露于与血清中药物最大浓度期间血液中可达到的浓度相当的浓度有关。
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