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Pathogenesis of infections related to intravascular catheterization.与血管内导管插入术相关感染的发病机制。
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Biofilm formation by Candida species on the surface of catheter materials in vitro.念珠菌属在体外导管材料表面形成生物膜。
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白色念珠菌生物膜体外对抗真菌剂的耐药性。

Resistance of Candida albicans biofilms to antifungal agents in vitro.

作者信息

Hawser S P, Douglas L J

机构信息

Laboratory of Microbiology, University of Glasgow, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1995 Sep;39(9):2128-31. doi: 10.1128/AAC.39.9.2128.

DOI:10.1128/AAC.39.9.2128
PMID:8540729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162894/
Abstract

Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms.

摘要

通过[3H]亮氨酸掺入和四氮唑还原试验测定，白色念珠菌在导管材料小圆盘上形成的生物膜对五种临床上重要的抗真菌剂的作用具有抗性。氟康唑表现出最大的活性，而两性霉素B对生物膜细胞的活性最低。生物膜的扫描电子显微镜检查证实了这些发现。