在接受地塞米松治疗的大鼠模型中评估高剂量巴龙霉素方案对隐孢子虫病的疗效。
Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model.
作者信息
Verdon R, Polianski J, Gaudebout C, Marche C, Garry L, Carbon C, Pocidalo J J
机构信息
Institut National de la Santé et de la Recherche Médicale, Unité 13, Hôpital Bichat-Claude-Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):2155-7. doi: 10.1128/AAC.39.9.2155.
Abstract
In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks after treatment, a persistent infection was demonstrated in all rats. These results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infection.
摘要
在地塞米松处理的隐孢子虫病大鼠模型中，对于回肠感染，巴龙霉素剂量为50毫克/千克/天或更高时有效，对于盲肠感染，剂量为200毫克/千克/天或更高时有效。治疗后1周和3周时，所有大鼠均显示存在持续性感染。这些结果证实了巴龙霉素的抗隐孢子虫活性，并强调了该化合物的局限性，因为其在如此高剂量下具有潜在毒性且无法根除感染。
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