在经地塞米松处理的大鼠模型中评价巴龙霉素的抗隐孢子虫治疗活性
Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model.
作者信息
Verdon R, Polianski J, Gaudebout C, Marche C, Garry L, Pocidalo J J
机构信息
Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude-Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1681-2. doi: 10.1128/AAC.38.7.1681.
Abstract
A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of paromomycin per kg of body weight per day.
摘要
使用地塞米松处理的隐孢子虫病大鼠模型来评估巴龙霉素的治疗活性。虽然未能证明寄生虫被根除，但在每天接受每千克体重100毫克巴龙霉素的动物中，观察到卵囊排泄和回肠寄生强度有统计学上的显著降低。
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2
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Clin Infect Dis. 1993 Feb;16(2):298-300. doi: 10.1093/clind/16.2.298.
3
Paromomycin is effective as prophylaxis for cryptosporidiosis in dairy calves.巴龙霉素作为预防奶牛犊隐孢子虫病的药物是有效的。
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4
Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice.
J Parasitol. 1993 Aug;79(4):553-8.
5
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