在经地塞米松处理的大鼠模型中评价巴龙霉素的抗隐孢子虫治疗活性
Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model.
作者信息
Verdon R, Polianski J, Gaudebout C, Marche C, Garry L, Pocidalo J J
机构信息
Institut National de la Santé et de la Recherche Médicale, Hôpital Bichat-Claude-Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1994 Jul;38(7):1681-2. doi: 10.1128/AAC.38.7.1681.
Abstract
A dexamethasone-treated rat model of cryptosporidiosis was used to evaluate the curative activity of paromomycin. Although eradication of the parasite could not be demonstrated, statistically significant decreases in oocyst excretion and in the intensity of ileal parasitism were observed in animals receiving 100 mg of paromomycin per kg of body weight per day.
摘要
使用地塞米松处理的隐孢子虫病大鼠模型来评估巴龙霉素的治疗活性。虽然未能证明寄生虫被根除，但在每天接受每千克体重100毫克巴龙霉素的动物中，观察到卵囊排泄和回肠寄生强度有统计学上的显著降低。
相似文献
1
Evaluation of curative anticryptosporidial activity of paromomycin in a dexamethasone-treated rat model.在经地塞米松处理的大鼠模型中评价巴龙霉素的抗隐孢子虫治疗活性
Antimicrob Agents Chemother. 1994 Jul;38(7):1681-2. doi: 10.1128/AAC.38.7.1681.
2
Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model.在接受地塞米松治疗的大鼠模型中评估高剂量巴龙霉素方案对隐孢子虫病的疗效。
Antimicrob Agents Chemother. 1995 Sep;39(9):2155-7. doi: 10.1128/AAC.39.9.2155.
3
A comparison of anticryptosporidial activity of paromomycin with that of other aminoglycosides and azithromycin in immunosuppressed rats.在免疫抑制大鼠中比较巴龙霉素与其他氨基糖苷类药物及阿奇霉素的抗隐孢子虫活性。
J Infect Dis. 1994 Oct;170(4):934-8. doi: 10.1093/infdis/170.4.934.
4
Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.硝唑尼特在免疫抑制大鼠模型中的持久抗隐孢子虫活性。
Folia Parasitol (Praha). 2003 Mar;50(1):19-22. doi: 10.14411/fp.2003.003.
5
Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice.天然多糖壳聚糖对新生小鼠体内外微小隐孢子虫的疗效
Exp Parasitol. 2018 Nov;194:1-8. doi: 10.1016/j.exppara.2018.09.003. Epub 2018 Sep 17.
6
Efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed gerbil model.硝唑尼特和巴龙霉素在免疫抑制沙鼠模型中治疗胆道隐孢子虫病的疗效
J Antimicrob Chemother. 2006 Feb;57(2):353-5. doi: 10.1093/jac/dki456. Epub 2005 Dec 16.
7
Chemoprophylaxis of Cryptosporidium parvum infection with paromomycin in kids and immunological study.用巴龙霉素对儿童隐孢子虫感染进行化学预防及免疫学研究。
Antimicrob Agents Chemother. 1995 Jan;39(1):75-8. doi: 10.1128/AAC.39.1.75.
8
Therapeutic efficacy of paromomycin in immunosuppressed adult mice infected with Cryptosporidium parvum.巴龙霉素对感染微小隐孢子虫的免疫抑制成年小鼠的治疗效果。
J Parasitol. 1995 Feb;81(1):114-6.
9
Comparative efficacy of curcumin and paromomycin against Cryptosporidium parvum infection in a BALB/c model.姜黄素与巴龙霉素对BALB/c模型中小隐孢子虫感染的疗效比较
Vet Parasitol. 2018 Jan 30;250:7-14. doi: 10.1016/j.vetpar.2017.12.008. Epub 2017 Dec 9.
10
Efficacy of mangiferin against Cryptosporidium parvum in a neonatal mouse model.芒果苷在新生小鼠模型中对微小隐孢子虫的疗效。
Parasitol Res. 2006 Jul;99(2):184-8. doi: 10.1007/s00436-006-0165-4. Epub 2006 Mar 18.
引用本文的文献
1
Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin.α-1-抗胰蛋白酶与巴龙霉素联合使用的协同抗隐孢子虫潜力
Antimicrob Agents Chemother. 1997 Sep;41(9):2006-8. doi: 10.1128/AAC.41.9.2006.
2
Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model.在接受地塞米松治疗的大鼠模型中评估高剂量巴龙霉素方案对隐孢子虫病的疗效。
Antimicrob Agents Chemother. 1995 Sep;39(9):2155-7. doi: 10.1128/AAC.39.9.2155.
本文引用的文献
1
Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.西奈芬净在免疫抑制成年大鼠模型中的抗隐孢子虫治疗和预防活性
Antimicrob Agents Chemother. 1993 Apr;37(4):889-92. doi: 10.1128/AAC.37.4.889.
2
Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS.
Clin Infect Dis. 1993 Feb;16(2):298-300. doi: 10.1093/clind/16.2.298.
3
Paromomycin is effective as prophylaxis for cryptosporidiosis in dairy calves.巴龙霉素作为预防奶牛犊隐孢子虫病的药物是有效的。
J Parasitol. 1993 Oct;79(5):771-4.
4
Glycoside antibiotics alone and combined with tetracyclines for prophylaxis of experimental cryptosporidiosis in neonatal BALB/c mice.
J Parasitol. 1993 Aug;79(4):553-8.
5
Characterization of a dexamethasone-treated rat model of cryptosporidial infection.地塞米松治疗的隐孢子虫感染大鼠模型的特征描述。
J Infect Dis. 1988 Dec;158(6):1406-7. doi: 10.1093/infdis/158.6.1406.
6
Paromomycin for the treatment of cryptosporidial diarrhoea in AIDS patients.巴龙霉素治疗艾滋病患者隐孢子虫性腹泻
AIDS. 1991 Sep;5(9):1146-7.
7
Cryptosporidiosis.隐孢子虫病
Clin Microbiol Rev. 1991 Jul;4(3):325-58. doi: 10.1128/CMR.4.3.325.
8
Activity of azithromycin against cryptosporidia in immunosuppressed rats.
J Infect Dis. 1991 Jun;163(6):1293-6. doi: 10.1093/infdis/163.6.1293.
9
Paromomycin inhibits Cryptosporidium infection of a human enterocyte cell line.巴龙霉素抑制人肠上皮细胞系的隐孢子虫感染。
J Infect Dis. 1992 Apr;165(4):772-4. doi: 10.1093/infdis/165.4.772.
10
Treatment of cryptosporidiosis with paromomycin. A report of five cases.
Arch Intern Med. 1992 Dec;152(12):2497-9.
Zotero 插件