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耻垢分枝杆菌rpoB基因的测序与分析

Sequence and analysis of the rpoB gene of Mycobacterium smegmatis.

作者信息

Hetherington S V, Watson A S, Patrick C C

机构信息

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

出版信息

Antimicrob Agents Chemother. 1995 Sep;39(9):2164-6. doi: 10.1128/AAC.39.9.2164.

DOI:10.1128/AAC.39.9.2164
PMID:8540740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162905/
Abstract

The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of resistance may be present.

摘要

rpoB基因编码细菌依赖DNA的RNA聚合酶的β亚基。特定区域的突变会导致对利福平产生耐药性。耻垢分枝杆菌天然对利福平耐药，但对rpoB基因的分析未发现可识别的利福平耐药突变。可能存在另一种耐药机制。

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本文引用的文献

1
Genetic evidence for the interaction between cluster I and cluster III rifampicin resistant mutations.第一类与第三类利福平耐药突变之间相互作用的遗传学证据。
J Mol Biol. 1993 May 5;231(1):1-5. doi: 10.1006/jmbi.1993.1251.
2
Molecular basis of rifampin resistance in Mycobacterium leprae.麻风分枝杆菌中利福平耐药性的分子基础。
Antimicrob Agents Chemother. 1993 Mar;37(3):414-8. doi: 10.1128/AAC.37.3.414.
3
Rapid amplification of genomic DNA ends.基因组DNA末端的快速扩增
Biotechniques. 1993 Aug;15(2):214-6.
4
Inactivation of rifampin by Nocardia brasiliensis.巴西诺卡菌对利福平的灭活作用。
Antimicrob Agents Chemother. 1993 Jun;37(6):1313-7. doi: 10.1128/AAC.37.6.1313.
5
Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase.利福平区域再探讨。大肠杆菌RNA聚合酶β亚基中新的耐利福平和耐链霉溶菌素突变体。
J Biol Chem. 1993 Jul 15;268(20):14820-5.
6
Mycobacterium smegmatis RNA polymerase: DNA supercoiling, action of rifampicin and mechanism of rifampicin resistance.耻垢分枝杆菌RNA聚合酶：DNA超螺旋、利福平的作用及利福平耐药机制
Mol Microbiol. 1993 Apr;8(2):277-85. doi: 10.1111/j.1365-2958.1993.tb01572.x.
7
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.结核分枝杆菌中利福平耐药性突变的检测
Lancet. 1993 Mar 13;341(8846):647-50. doi: 10.1016/0140-6736(93)90417-f.
8
Evaluation of the rpoB gene in rifampicin-susceptible and -resistant Mycobacterium avium and Mycobacterium intracellulare.对结核分枝杆菌鸟型和胞内分枝杆菌中利福平敏感及耐药菌株的rpoB基因评估。
J Antimicrob Chemother. 1994 Mar;33(3):661-3. doi: 10.1093/jac/33.3.661-a.
9
The rpoB gene of Mycobacterium tuberculosis.结核分枝杆菌的rpoB基因。
Antimicrob Agents Chemother. 1994 Apr;38(4):805-11. doi: 10.1128/AAC.38.4.805.
10
Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.通过自动DNA测序对来自纽约市和得克萨斯州的耐利福平结核分枝杆菌菌株中编码RNA聚合酶β亚基的基因（rpoB）突变进行特征分析。
J Clin Microbiol. 1994 Apr;32(4):1095-8. doi: 10.1128/jcm.32.4.1095-1098.1994.