耻垢分枝杆菌rpoB基因的测序与分析
Sequence and analysis of the rpoB gene of Mycobacterium smegmatis.
作者信息
Hetherington S V, Watson A S, Patrick C C
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
出版信息
Antimicrob Agents Chemother. 1995 Sep;39(9):2164-6. doi: 10.1128/AAC.39.9.2164.
Abstract
The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of resistance may be present.
摘要
rpoB基因编码细菌依赖DNA的RNA聚合酶的β亚基。特定区域的突变会导致对利福平产生耐药性。耻垢分枝杆菌天然对利福平耐药，但对rpoB基因的分析未发现可识别的利福平耐药突变。可能存在另一种耐药机制。
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