Hollister J M, Laing P, Mednick S A
University of Pennsylvania, Philadelphia, USA.
Arch Gen Psychiatry. 1996 Jan;53(1):19-24. doi: 10.1001/archpsyc.1996.01830010021004.
Rhesus (Rh) incompatibility is a cause of hemolytic disease of the fetus and newborn. Hemolytic disease results from the transplacentally transmitted maternal antibodies against Rh factor D and can cause permanent neurological damage in the affected newborn. This study examines the hypothesis that Rh incompatibility may be a risk factor for schizophrenia.
A sample of 1867 male subjects was divided into two groups, 535 Rh incompatible and 1332 Rh compatible, and compared on rate of schizophrenia.
The rate of schizophrenia was significantly higher in the Rh-incompatible group (2.1%) compared with the Rh-compatible group (0.8%) (P < .03). In addition, since the risk for Rh hemolytic disease increases with second and later Rh incompatible pregnancies, it is noteworthy that the second- and later-born incompatible offspring exhibited a significantly higher rate of schizophrenia than second- and later-born compatible offspring (P < .05). Also, as predicted, the rate of schizophrenia among firstborn incompatible subjects was not significantly different from that of firstborn compatible subjects (1.1% vs 0.7%).
Rh incompatibility may be a risk factor for schizophrenia.
恒河猴（Rh）血型不相容是胎儿和新生儿溶血病的一个病因。溶血病是由经胎盘传播的母体抗Rh因子D抗体引起的，可导致受影响新生儿永久性神经损伤。本研究检验了Rh血型不相容可能是精神分裂症危险因素这一假说。
1867名男性受试者样本被分为两组，535名Rh血型不相容者和1332名Rh血型相容者，并比较了精神分裂症发病率。
Rh血型不相容组的精神分裂症发病率（2.1%）显著高于Rh血型相容组（0.8%）（P < 0.03）。此外，由于Rh溶血病的风险随着第二次及以后的Rh血型不相容妊娠而增加，值得注意的是，第二次及以后出生的不相容后代患精神分裂症的比例显著高于第二次及以后出生的相容后代（P < 0.05）。同样，正如预期的那样，第一胎不相容受试者的精神分裂症发病率与第一胎相容受试者的发病率无显著差异（1.1%对0.7%）。
Rh血型不相容可能是精神分裂症的一个危险因素。
