McCoy M C, Wang Y, Coffman T M, Killam A P, Kay H H
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Am J Perinatol. 1995 Sep;12(5):371-4. doi: 10.1055/s-2007-994499.
Polyunsaturated fatty acids play an important yet poorly understood role in pregnancy complications. We are interested in the effects of aspirin therapy on the metabolism of these compounds. To determine the effects of low-dose aspirin on plasma levels of polyunsaturated fatty acid precursors, we assayed linoleic, linolenic, arachidonic, eicosapentaenoic, and docosahexaenoic acids using high-performance liquid chromatography. Seventeen pregnant women being treated with aspirin therapy (81 mg/day) were evaluated between 9 and 37 weeks' gestation. Blood was drawn before initiation of aspirin therapy and after 3 or 4 days, and again after 3 or 4 weeks of therapy. We found no significant change in the plasma levels of fatty acids during aspirin therapy at either 3 or 4 days or 3 or 4 weeks compared with baseline. In this group of women with preexisting disease, low-dose aspirin does not appear to change the plasma levels of polyunsaturated fatty acid precursors of eicosanoids. Data on pregnant women without hypertensive disorders is needed to help in understanding the role and physiology of these important compounds.
多不饱和脂肪酸在妊娠并发症中发挥着重要作用，但其作用机制却鲜为人知。我们对阿司匹林治疗对这些化合物代谢的影响感兴趣。为了确定低剂量阿司匹林对多不饱和脂肪酸前体血浆水平的影响，我们使用高效液相色谱法测定了亚油酸、亚麻酸、花生四烯酸、二十碳五烯酸和二十二碳六烯酸。对17名接受阿司匹林治疗（81毫克/天）的孕妇在妊娠9至37周期间进行了评估。在开始阿司匹林治疗前、治疗3或4天后以及治疗3或4周后采集血液。我们发现，与基线相比，在阿司匹林治疗3或4天或3或4周期间，脂肪酸的血浆水平没有显著变化。在这组患有基础疾病的女性中，低剂量阿司匹林似乎不会改变类花生酸多不饱和脂肪酸前体的血浆水平。需要关于无高血压疾病孕妇的数据，以帮助了解这些重要化合物的作用和生理学。
