Wang Y P, Kay H H, Killam A P
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710.
Am J Obstet Gynecol. 1991 Mar;164(3):812-8. doi: 10.1016/0002-9378(91)90521-r.
Plasma levels of polyunsaturated fatty acids in the n-3 and n-6 classes, which include linoleic, linolenic, arachidonic, eicosapentaenoic, and docosahexaenoic acids, were quantified with high-performance liquid chromatography in nonpregnant volunteers and in patients with normal pregnancies or preeclampsia at term. The total polyunsaturated fatty acid levels were not significantly different between nonpregnant and normal pregnant patients but was significantly lower in the preeclamptic patients compared with normal pregnant patients. This decreased level could represent altered fatty acid metabolism or altered storage and mobilization from lipid pools. Compared with nonpregnant patients, normal pregnant patients had significantly higher levels of eicosapentaenoic and docosahexaenoic acid. This may reflect normal physiologic changes in pregnancy, and the decreased level of eicosapentaenoic acid seen in preeclamptic patients may play a significant role in the pathophysiology of preeclampsia.
采用高效液相色谱法对非妊娠志愿者以及足月正常妊娠或子痫前期患者体内n-3和n-6类多不饱和脂肪酸的血浆水平进行了定量分析，这些多不饱和脂肪酸包括亚油酸、亚麻酸、花生四烯酸、二十碳五烯酸和二十二碳六烯酸。非妊娠患者与正常妊娠患者的总多不饱和脂肪酸水平无显著差异，但子痫前期患者的总多不饱和脂肪酸水平显著低于正常妊娠患者。这种水平降低可能代表脂肪酸代谢改变，或脂质池储存及动员的改变。与非妊娠患者相比，正常妊娠患者的二十碳五烯酸和二十二碳六烯酸水平显著更高。这可能反映了妊娠期间的正常生理变化，而子痫前期患者中二十碳五烯酸水平降低可能在子痫前期的病理生理学中起重要作用。
