Jacobson L P, Armenian H K
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Curr Opin Oncol. 1995 Sep;7(5):450-5. doi: 10.1097/00001622-199509000-00011.
As an AIDS-defining illness, Kaposi's sarcoma primarily occurs among HIV-infected homosexual men in developed countries and among men and women in Africa. Except in Africa, Kaposi's sarcoma was rarely diagnosed prior to the AIDS epidemic. The clustering of cases geographically and by gender suggest an environmental influence. Epidemiologic evidence of an infectious cofactor for the disease is presented with the recent findings of herpetic-like viral DNA in Kaposi's sarcoma tissue. Observations indicate that this putative cofactor is sexually transmitted. A model is provided that integrates the virologic and epidemiologic components in the etiology of Kaposi's sarcoma.
作为一种艾滋病界定疾病，卡波西肉瘤主要发生在发达国家感染艾滋病毒的男同性恋者以及非洲的男性和女性中。除非洲外，在艾滋病流行之前很少诊断出卡波西肉瘤。病例在地理上和性别上的聚集表明存在环境影响。随着最近在卡波西肉瘤组织中发现疱疹样病毒DNA，出现了该疾病感染性辅助因子的流行病学证据。观察表明，这种假定的辅助因子是通过性传播的。提供了一个模型，该模型整合了卡波西肉瘤病因学中的病毒学和流行病学成分。
