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[切尔诺贝利核电站事故后受小剂量电离辐射儿童的DNA修复活性]

[Dna repair activity in children exposed to small doses of ionizing radiation as a result of the accident at the Chernobyl nuclear power station].

作者信息

Unizhakov S V, L'vova G N, Chekova V V, Semiachkina A N, Baleva L S, Zasukhina G D, Kazantseva L Z

出版信息

Genetika. 1995 Oct;31(10):1433-7.

PMID:8543145
Abstract

The repair activity of DNA was studied by variola vaccine virus reactivation and induced mutagenesis tests in the peripheral blood lymphocytes of children living in areas with an increased level of ionizing radiation due to breakdown at the Chernobyl' nuclear power station. A more profound repair disturbance was revealed in children living on strictly controlled territories and born after the disaster, compared to those born before it, and children living in areas where the radiation level does not exceed background values. The disturbances were characterized by increased induced mutagenesis and decreased reactivation of the variola vaccine virus. No changes in the degree of DNA repair synthesis were registered in any of the groups studied.

摘要

通过在切尔诺贝利核电站事故后电离辐射水平升高地区居住的儿童外周血淋巴细胞中进行天花疫苗病毒复活和诱导诱变试验,研究了DNA的修复活性。与灾难前出生的儿童以及生活在辐射水平不超过本底值地区的儿童相比,在严格控制区域内居住且灾难后出生的儿童表现出更严重的修复障碍。这些障碍的特征是诱导诱变增加以及天花疫苗病毒复活减少。在所研究的任何组中均未发现DNA修复合成程度的变化。

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