Majumder P P, Nayak S, Das R N, Bhattacharya S K
Anthropometry & Human Genetics Unit, Indian Statistical Institute, Calcutta.
Indian J Med Res. 1996 Feb;103:112-9.
A genetic epidemiological study of serum lipid and lipoprotein levels was conducted among families of Marwaris residents in Calcutta. A total of 210 families, comprising over 100 individuals, were studied. Analyses were performed to estimate the genetic and environmental effects on the determination of high density lipoprotein cholesterol (HDL-C) and serum triglycerides (TG). Familial correlations for HDL-C and TG were estimated: parent-child and sib-sib correlations were found to be significant. Spouse correlations were not significant. Correlations between environments of siblings were significant. Genetic analysis of data on HDL-C and TG performed under a path model, taking genetic transmission and possible environmental associations among family members into account, indicated that lipid and lipoprotein levels adjusted and standardized for age, gender, education, occupation and disease status are primarily determined by genetic factors. The effects of environmental factors were also significant, although in comparison with genetic factors these effects were much smaller. The estimated genetic heritability for HDL-C was approximately 80 per cent, while that for TG was approximately 55 per cent. The genetic effects and environmental effects were not significantly different between adults and children.
在加尔各答马尔瓦尔居民家庭中开展了一项关于血脂和脂蛋白水平的遗传流行病学研究。共研究了210个家庭，涵盖100多名个体。进行分析以估计遗传和环境因素对高密度脂蛋白胆固醇（HDL-C）和血清甘油三酯（TG）测定的影响。估计了HDL-C和TG的家族相关性：发现亲子和同胞间的相关性显著。配偶间的相关性不显著。兄弟姐妹间环境的相关性显著。在考虑遗传传递和家庭成员间可能的环境关联的路径模型下，对HDL-C和TG数据进行的遗传分析表明，针对年龄、性别、教育程度、职业和疾病状况进行调整和标准化后的血脂和脂蛋白水平主要由遗传因素决定。环境因素的影响也很显著，不过与遗传因素相比，这些影响要小得多。HDL-C的估计遗传度约为80%，而TG的约为55%。成人和儿童之间的遗传效应和环境效应没有显著差异。
