Spratt J S, Meyer J S, Spratt J A
Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, KY 40202, USA.
J Surg Oncol. 1996 Jan;61(1):68-83. doi: 10.1002/1096-9098(199601)61:1<68::aid-jso2930610102>3.0.co;2-e.
Part I of this study [Spratt JS, Meyer JS, Spratt JA: J Surg Oncol 60:137-146, 1995] reviewed the early reports of investigators, predominantly mathematical biologists and statisticians considering the mathematical laws that would describe the growth of a neoplasm. Included were cytokinetic measurements of the mitotic index, thymidine labeling index, bromodeoxy-uridine labeling index, and the relation of these indices to the potential tumor volume doubling time. The actual doubling time of benign and malignant colonic neoplasms were reported. This second part provides the cumulative observations on the actual doubling times of pulmonary metastases, primary pulmonary cancers, skeletal sarcomas, melanomas, a chemodectoma, tumors of maxillary antrum, testicular cancers, prostate cancer, and the relation between the accumulation of multiple primary cancers and growth rates. The most complete data set is for breast cancer concluding that the cancer growth curve is a decelerating curve with great natural variance. Understanding of the rates of growth of human cancers is essential for understanding the spectrum of cancer behavior observed clinically.
本研究的第一部分[斯普拉特JS、迈耶JS、斯普拉特JA：《外科肿瘤学杂志》60:137 - 146，1995年]回顾了研究人员的早期报告，这些研究人员主要是数学生物学家和统计学家，他们思考描述肿瘤生长的数学规律。其中包括有丝分裂指数、胸腺嘧啶核苷标记指数、溴脱氧尿苷标记指数的细胞动力学测量，以及这些指数与潜在肿瘤体积倍增时间的关系。报告了良性和恶性结肠肿瘤的实际倍增时间。第二部分提供了关于肺转移瘤、原发性肺癌、骨肉瘤、黑色素瘤、化学感受器瘤、上颌窦肿瘤、睾丸癌、前列腺癌实际倍增时间的累积观察结果，以及多发性原发性癌症的累积与生长速率之间的关系。关于乳腺癌的数据集最为完整，得出的结论是癌症生长曲线是一条具有很大自然变异性的减速曲线。了解人类癌症的生长速率对于理解临床上观察到的癌症行为谱至关重要。
