Spratt J S, Meyer J S, Spratt J A
Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Kentucky 40202, USA.
J Surg Oncol. 1995 Oct;60(2):137-46. doi: 10.1002/jso.2930600216.
The purpose of this article is to consolidate data collected from a variety of sources that have permitted calculations of the rates of growth of human neoplasms. These sources include Fischel State Cancer Hospital (Columbia, MO); Mallinckrodt Institute of Radiology, (St. Louis, MO); Roentgen Diagnostic Institute, Allmanna Sjukhuset (Malmo, Sweden); University of Louisville (Louisville, Kentucky); University of Heidelberg (Heidelberg, Germany); and St. Luke's Hospital (St. Louis, MO). Included in the data are laboratory measurements of cell replication rates. All gross measurements were made either on imaging studies or with a centimeter scale for surface or palpable neoplasms. Data have been reported for breast and pulmonary cancers and metastases of many types, melanomas, skeletal sarcomas, benign and malignant colonic neoplasms, and isolated cases of less frequent neoplasms. Related cytokinetic measurements by tritriated thymidine labelling, bromodeoxyuridine labelling, S-phase fraction from DNA flow cytometric analysis, and mitotic indices are discussed. The various mathematical formulae applicable to the analysis of the collected data and the determination of rates and patterns of growth are included. Also considered are the clinical implications of these data and the importance of ever better knowledge on the cytokinetics of human cancer. Prior studies on the evolution of insight into this field are cited and discussed. The authors conclude that a more accurate quantification of the growth rates of human cancer is essential for understanding the biological variance of human cancers seen clinically.
本文的目的是整合从各种来源收集的数据，这些数据允许计算人类肿瘤的生长速率。这些来源包括菲舍尔州立癌症医院（密苏里州哥伦比亚）；马林克罗德放射研究所（密苏里州圣路易斯）；阿勒曼纳 sjukhuset 的伦琴诊断研究所（瑞典马尔默）；路易斯维尔大学（肯塔基州路易斯维尔）；海德堡大学（德国海德堡）；以及圣卢克医院（密苏里州圣路易斯）。数据中包括细胞复制速率的实验室测量值。所有大体测量均在影像学研究中进行，或对于体表或可触及的肿瘤使用厘米尺进行测量。已报告了乳腺癌、肺癌及多种类型转移瘤、黑色素瘤、骨肉瘤、良性和恶性结肠肿瘤以及较少见肿瘤的孤立病例的数据。还讨论了通过氚标记胸腺嘧啶核苷标记、溴脱氧尿苷标记、DNA 流式细胞术分析的 S 期分数以及有丝分裂指数进行的相关细胞动力学测量。文中包含了适用于分析所收集数据以及确定生长速率和模式的各种数学公式。还考虑了这些数据的临床意义以及对人类癌症细胞动力学有更深入了解的重要性。文中引用并讨论了此前关于该领域认识发展的研究。作者得出结论，更准确地量化人类癌症的生长速率对于理解临床上所见人类癌症的生物学差异至关重要。
