Cichon J V, McCaffrey T V, Litchy W J, Knops J L
Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA.
Laryngoscope. 1995 Feb;105(2):144-8. doi: 10.1288/00005537-199502000-00006.
Serial measurements were performed on the compound muscle action potential (CMAP) amplitude and the force generated by the rat lower hind limb flexors to investigate the time course of intramuscular injections of botulinum toxin type A (BOTOX). Thirty animals were used in this in vivo rat model. CMAP amplitude and muscle force were measured at predetermined intervals for 28 weeks. Compound muscle action potential amplitude and force declined markedly the first 5 to 7 days after injection of BOTOX but recovered in a near linear manner. The response magnitude and recovery rate were dose-dependent. Recovery of CMAP amplitude preceded recovery of muscle force. No clear evidence of a systemic effect on the untreated leg or a concentration effect was found. CMAP amplitude may be useful in determining optimal timing of repeat injections in treating neuromuscular disorders.
对大鼠后肢屈肌产生的复合肌肉动作电位（CMAP）幅度和力量进行连续测量，以研究肌肉注射A型肉毒杆菌毒素（保妥适）的时间进程。在这个体内大鼠模型中使用了30只动物。在28周内按预定间隔测量CMAP幅度和肌肉力量。注射保妥适后的前5至7天，复合肌肉动作电位幅度和力量显著下降，但以近似线性的方式恢复。反应幅度和恢复率呈剂量依赖性。CMAP幅度的恢复先于肌肉力量的恢复。未发现对未治疗腿部有明显的全身效应或浓度效应的证据。CMAP幅度可能有助于确定治疗神经肌肉疾病时重复注射的最佳时机。
