Cole J, Green M H
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
Mutagenesis. 1995 Sep;10(5):449-52. doi: 10.1093/mutage/10.5.449.
A substantial database on hprt mutant frequency in circulating T-cells derived from 153 normal humans was analysed to determine if any effect of alcohol consumption could be detected. Alcohol intake (as reported in a questionnaire completed at the time of the blood sample) ranged from 0 to 35+ units per week. Donors were classified into four groups, including total abstainers (n = 18); those who consumed less than the Royal College of Physicians guideline (men, 21 units; women, 14 units) (n = 113); those who consumed more than the guideline value (n = 12); and designated alcohol-dependent subjects (n = 10). No significant difference in mutant frequency between the four groups was found, nor was an overall correlation between alcohol consumption and mutant frequency seen.
分析了一个来自153名正常人类的循环T细胞中hprt突变频率的大量数据库，以确定是否能检测到饮酒的任何影响。酒精摄入量（如在采集血样时填写的问卷中所报告）每周从0到35个单位以上不等。捐赠者被分为四组，包括完全戒酒者（n = 18）；饮酒量低于皇家内科医师学会指南（男性21个单位；女性14个单位）的人（n = 113）；饮酒量超过指南值的人（n = 12）；以及指定的酒精依赖者（n = 10）。四组之间的突变频率没有显著差异，饮酒量与突变频率之间也没有总体相关性。
