Sullivan E V, Marsh L, Mathalon D H, Lim K O, Pfefferbaum A
Psychiatry Service, Department of Veterans Affairs Health Care System, Palo Alto, CA 94304, USA.
Neurobiol Aging. 1995 Jul-Aug;16(4):591-606. doi: 10.1016/0197-4580(95)00074-o.
The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly correlated with age. By contrast, left and right temporal lobe gray matter volumes, exclusive of the hippocampal measures, each decreased with age (p < 0.01). Volumes of temporal lobe sulcal CSF and the ventricular system (temporal horns and lateral and third ventricles) significantly increased with age. Measures of verbal and nonverbal working memory showed age-related declines and were related to enlargement of the three ventricular regions, which may be indicative of age-related atrophy of the adjacent cortex but not the hippocampus, at least up to age 70 years.
通过定量磁共振成像（MRI）对72名年龄跨度为5个十年（21至70岁）的健康男性进行横断面评估，以研究正常衰老对海马体和颞叶皮质体积的影响。海马体和皮质白质体积均与年龄无显著相关性。相比之下，排除海马体测量值后，左、右颞叶灰质体积均随年龄下降（p < 0.01）。颞叶脑沟脑脊液和脑室系统（颞角、侧脑室和第三脑室）的体积随年龄显著增加。言语和非言语工作记忆测量显示出与年龄相关的下降，并且与三个脑室区域的扩大有关，这可能表明至少到70岁，相邻皮质存在与年龄相关的萎缩，但海马体没有。
