• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

老年人大脑高分辨率 0.5mm 各向同性 T1 加权模板的建立与评估。

Development and evaluation of a high resolution 0.5mm isotropic T1-weighted template of the older adult brain.

机构信息

Department of Biomedical Engineering, Illinois Institute of Technology, 3440 S Dearborn St, M-100, Chicago, IL 60616, United States.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

出版信息

Neuroimage. 2022 Mar;248:118869. doi: 10.1016/j.neuroimage.2021.118869. Epub 2022 Jan 2.

DOI:10.1016/j.neuroimage.2021.118869
PMID:34986396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8855670/
Abstract

Investigating the structure of the older adult brain at high spatial resolution is of high significance, and a dedicated older adult structural brain template with sub-millimeter resolution is currently lacking. Therefore, the purpose of this work was twofold: (A) to develop a 0.5mm isotropic resolution standardized T1-weighted template of the older adult brain by applying principles of super resolution to high quality MRI data from 222 older adults (65-95 years of age), and (B) to systematically compare the new template to other standardized and study-specific templates in terms of image quality and performance when used as a reference for alignment of older adult data. The new template exhibited higher spatial resolution and improved visualization of fine structural details of the older adult brain compared to a template constructed using a conventional template building approach and the same data. In addition, the new template exhibited higher image sharpness and did not contain image artifacts observed in some of the other templates considered in this work. Due to the above enhancements, the new template provided higher inter-subject spatial normalization precision for older adult data compared to the other templates, and consequently enabled detection of smaller inter-group morphometric differences in older adult data. Finally, the new template was among those that were most representative of older adult brain data. Overall, the new template constructed here is an important resource for studies of aging, and the findings of the present work have important implications in template selection for investigations on older adults.

摘要

高空间分辨率研究老年人大脑结构具有重要意义，但目前缺乏具有亚毫米分辨率的专门老年人大脑结构模板。因此，这项工作的目的有两个：（A）通过将超分辨率原理应用于 222 名老年人大脑（65-95 岁）的高质量 MRI 数据，开发出具有 0.5 毫米各向同性分辨率的老年人大脑标准化 T1 加权模板；（B）系统地比较新模板与其他标准化和特定于研究的模板在用作老年人大脑数据配准参考时的图像质量和性能。与使用传统模板构建方法和相同数据构建的模板相比，新模板显示出更高的空间分辨率和更好的老年人大脑精细结构细节的可视化效果。此外，新模板显示出更高的图像锐度，并且没有包含本工作中考虑的其他一些模板中观察到的图像伪影。由于上述增强，新模板为老年人大脑数据提供了比其他模板更高的受试者间空间归一化精度，从而能够检测到老年人大脑数据中更小的组间形态差异。最后，新模板是最能代表老年人大脑数据的模板之一。总体而言，这里构建的新模板是研究衰老的重要资源，本工作的发现对老年人大脑研究中的模板选择具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/840be2597f4f/nihms-1777438-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/087cd4b4290e/nihms-1777438-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/37effc6faf3f/nihms-1777438-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/78035ce25ab1/nihms-1777438-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/d6d0f3dc48b0/nihms-1777438-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/97fdda65eb17/nihms-1777438-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/ab2554d5e81e/nihms-1777438-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/b32c7355d402/nihms-1777438-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/427fec0801de/nihms-1777438-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/39ac6d87a87f/nihms-1777438-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/10e4fdb02961/nihms-1777438-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/840be2597f4f/nihms-1777438-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/087cd4b4290e/nihms-1777438-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/37effc6faf3f/nihms-1777438-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/78035ce25ab1/nihms-1777438-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/d6d0f3dc48b0/nihms-1777438-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/97fdda65eb17/nihms-1777438-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/ab2554d5e81e/nihms-1777438-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/b32c7355d402/nihms-1777438-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/427fec0801de/nihms-1777438-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/39ac6d87a87f/nihms-1777438-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/10e4fdb02961/nihms-1777438-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c770/8855670/840be2597f4f/nihms-1777438-f0011.jpg

相似文献

1
Development and evaluation of a high resolution 0.5mm isotropic T1-weighted template of the older adult brain.老年人大脑高分辨率 0.5mm 各向同性 T1 加权模板的建立与评估。
Neuroimage. 2022 Mar;248:118869. doi: 10.1016/j.neuroimage.2021.118869. Epub 2022 Jan 2.
2
High resolution 0.5mm isotropic T-weighted and diffusion tensor templates of the brain of non-demented older adults in a common space for the MIITRA atlas.为 MIITRA 图谱构建非痴呆老年人大脑的高分辨率 0.5mm 各向同性 T 加权和弥散张量模板的通用空间。
Neuroimage. 2023 Nov 15;282:120387. doi: 10.1016/j.neuroimage.2023.120387. Epub 2023 Oct 1.
3
Development and evaluation of a high performance T1-weighted brain template for use in studies on older adults.用于老年人研究的高性能 T1 加权脑模板的开发和评估。
Hum Brain Mapp. 2021 Apr 15;42(6):1758-1776. doi: 10.1002/hbm.25327. Epub 2021 Jan 15.
4
Development of high quality T-weighted and diffusion tensor templates of the older adult brain in a common space.在通用空间中开发高质量的老年人大脑 T 加权和扩散张量模板。
Neuroimage. 2022 Oct 15;260:119417. doi: 10.1016/j.neuroimage.2022.119417. Epub 2022 Jul 3.
5
Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: Template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences.成人脑标准和特定研究弥散张量成像模板的评估：模板特征、空间归一化准确性和小的组间 FA 差异的检测。
Neuroimage. 2018 May 15;172:40-50. doi: 10.1016/j.neuroimage.2018.01.046. Epub 2018 Jan 28.
6
Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA).从定量磁化率图 (QSM) 计算模板的方法：迈向改进的图谱和体素基分析 (VBA)。
J Magn Reson Imaging. 2017 Nov;46(5):1474-1484. doi: 10.1002/jmri.25671. Epub 2017 Mar 6.
7
Enhanced ICBM diffusion tensor template of the human brain.人类大脑的增强型洲际弹道导弹扩散张量模板。
Neuroimage. 2011 Jan 15;54(2):974-84. doi: 10.1016/j.neuroimage.2010.09.008. Epub 2010 Sep 19.
8
Vervet MRI atlas and label map for fully automated morphometric analyses.用于全自动形态计量分析的绿猴MRI图谱和标签图。
Neuroinformatics. 2014 Oct;12(4):543-50. doi: 10.1007/s12021-014-9231-8.
9
Development of new population-averaged standard templates for spatial normalization and segmentation of MR images for postnatal piglet brains.用于新生仔猪脑磁共振图像空间归一化和分割的新的群体平均标准模板的开发。
Magn Reson Imaging. 2014 Dec;32(10):1396-402. doi: 10.1016/j.mri.2014.08.036. Epub 2014 Aug 29.
10
A study-specific fMRI normalization approach that operates directly on high resolution functional EPI data at 7 Tesla.一种特定于研究的功能磁共振成像（fMRI）归一化方法，该方法直接对7特斯拉的高分辨率功能回波平面成像（EPI）数据进行操作。
Neuroimage. 2014 Oct 15;100:710-4. doi: 10.1016/j.neuroimage.2014.06.045. Epub 2014 Jun 25.

引用本文的文献

1
The application of super-resolution ultrasound radiomics models in predicting the failure of conservative treatment for ectopic pregnancy.超分辨率超声影像组学模型在预测异位妊娠保守治疗失败中的应用
Reprod Biol Endocrinol. 2025 Jul 17;23(1):102. doi: 10.1186/s12958-025-01437-5.
2
Super resolution using sparse sampling at portable ultra-low field MR.便携式超低场磁共振成像中基于稀疏采样的超分辨率技术
Front Neurol. 2024 May 24;15:1330203. doi: 10.3389/fneur.2024.1330203. eCollection 2024.
3
High resolution 0.5mm isotropic T-weighted and diffusion tensor templates of the brain of non-demented older adults in a common space for the MIITRA atlas.

本文引用的文献

1
Development and evaluation of a high performance T1-weighted brain template for use in studies on older adults.用于老年人研究的高性能 T1 加权脑模板的开发和评估。
Hum Brain Mapp. 2021 Apr 15;42(6):1758-1776. doi: 10.1002/hbm.25327. Epub 2021 Jan 15.
2
pBrain: A novel pipeline for Parkinson related brain structure segmentation.pBrain：一种用于帕金森相关脑结构分割的新流水线。
Neuroimage Clin. 2020;25:102184. doi: 10.1016/j.nicl.2020.102184. Epub 2020 Jan 15.
3
Multiscale brain MRI super-resolution using deep 3D convolutional networks.
为 MIITRA 图谱构建非痴呆老年人大脑的高分辨率 0.5mm 各向同性 T 加权和弥散张量模板的通用空间。
Neuroimage. 2023 Nov 15;282:120387. doi: 10.1016/j.neuroimage.2023.120387. Epub 2023 Oct 1.
4
Development of high quality T-weighted and diffusion tensor templates of the older adult brain in a common space.在通用空间中开发高质量的老年人大脑 T 加权和扩散张量模板。
Neuroimage. 2022 Oct 15;260:119417. doi: 10.1016/j.neuroimage.2022.119417. Epub 2022 Jul 3.
5
Deep-learning-based 3D super-resolution MRI radiomics model: superior predictive performance in preoperative T-staging of rectal cancer.基于深度学习的 3D 超分辨率 MRI 放射组学模型：在直肠癌术前 T 分期中的预测性能优势。
Eur Radiol. 2023 Jan;33(1):1-10. doi: 10.1007/s00330-022-08952-8. Epub 2022 Jun 21.
6
Simultaneous high-resolution T -weighted imaging and quantitative T mapping at low magnetic field strengths using a multiple TE and multi-orientation acquisition approach.采用多回波和多方位采集方法在低磁场强度下进行同时高分辨率 T -加权成像和定量 T 映射。
Magn Reson Med. 2022 Sep;88(3):1273-1281. doi: 10.1002/mrm.29273. Epub 2022 May 12.
基于深度三维卷积网络的多尺度脑 MRI 超分辨率方法。
Comput Med Imaging Graph. 2019 Oct;77:101647. doi: 10.1016/j.compmedimag.2019.101647. Epub 2019 Aug 14.
4
Automated brain extraction of multisequence MRI using artificial neural networks.基于人工神经网络的多序列 MRI 自动脑区提取
Hum Brain Mapp. 2019 Dec 1;40(17):4952-4964. doi: 10.1002/hbm.24750. Epub 2019 Aug 12.
5
The Lifespan Human Connectome Project in Aging: An overview.衰老中的全生命周期人类连接组计划：概述。
Neuroimage. 2019 Jan 15;185:335-348. doi: 10.1016/j.neuroimage.2018.10.009. Epub 2018 Oct 15.
6
Simultaneous single- and multi-contrast super-resolution for brain MRI images based on a convolutional neural network.基于卷积神经网络的脑 MRI 图像的同步单对比度和多对比度超分辨率。
Comput Biol Med. 2018 Aug 1;99:133-141. doi: 10.1016/j.compbiomed.2018.06.010. Epub 2018 Jun 14.
7
Religious Orders Study and Rush Memory and Aging Project.宗教秩序研究和冲刺记忆与衰老项目。
J Alzheimers Dis. 2018;64(s1):S161-S189. doi: 10.3233/JAD-179939.
8
Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: Template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences.成人脑标准和特定研究弥散张量成像模板的评估：模板特征、空间归一化准确性和小的组间 FA 差异的检测。
Neuroimage. 2018 May 15;172:40-50. doi: 10.1016/j.neuroimage.2018.01.046. Epub 2018 Jan 28.
9
Comparing CAT12 and VBM8 for Detecting Brain Morphological Abnormalities in Temporal Lobe Epilepsy.比较CAT12和VBM8在检测颞叶癫痫脑形态学异常中的应用
Front Neurol. 2017 Aug 24;8:428. doi: 10.3389/fneur.2017.00428. eCollection 2017.
10
Effects of Spatial Resolution on Image Registration.空间分辨率对图像配准的影响。
Proc SPIE Int Soc Opt Eng. 2016 Feb 27;9784. doi: 10.1117/12.2217322. Epub 2016 Mar 21.