Poggioli R, Benelli A, Arletti R, Cavazzuti E, Bertolini A
Department of Biomedical Sciences, University of Modena, Italy.
Peptides. 1995;16(7):1263-8. doi: 10.1016/0196-9781(95)02014-n.
In many animal species, the ICV injection of ACTH and of several shorter sequences of the ACTH molecule (melanocortin peptides) induces a peculiar behavioral syndrome mainly characterized by excessive grooming and by repeated acts of stretching and yawning. In adult males, spontaneous penile erections with ejaculation are also induced. We have studied the effect of NO synthase inhibition on this behavioral syndrome. The IP injection of the NO synthase inhibitor L-NG-nitroarginine methyl ester (NAME) significantly prevented--at the doses of 50 and 100 mg/kg--all the behavioral symptoms induced by the ICV administration of ACTH(1-24) (4 micrograms/rat). On the other hand, the ICV injection of NAME (up to 300 micrograms/rat) had no influence on the ACTH-induced excessive grooming and stretching, while significantly inhibited the display of yawnings and penile erections. These data indicate that brain NO synthase is involved in the mechanism of ACTH-induced yawning and penile erections, whereas peripheral NO synthase is involved in the induction of stretching and grooming.
在许多动物物种中，脑室内注射促肾上腺皮质激素（ACTH）以及ACTH分子的几个较短序列（促黑素细胞激素肽）会诱发一种特殊的行为综合征，其主要特征为过度梳理毛发以及反复伸展和打哈欠。在成年雄性动物中，还会诱发伴有射精的自发性阴茎勃起。我们研究了一氧化氮合酶抑制对这种行为综合征的影响。腹腔注射一氧化氮合酶抑制剂L-硝基精氨酸甲酯（NAME），剂量为50和100mg/kg时，可显著预防脑室内注射促肾上腺皮质激素（1-24）（4微克/大鼠）所诱发的所有行为症状。另一方面，脑室内注射NAME（高达300微克/大鼠）对促肾上腺皮质激素诱发的过度梳理毛发和伸展行为没有影响，但能显著抑制打哈欠和阴茎勃起的表现。这些数据表明，脑内一氧化氮合酶参与促肾上腺皮质激素诱发打哈欠和阴茎勃起的机制，而外周一氧化氮合酶参与伸展和梳理毛发行为的诱发。
