Poggioli R, Arletti R, Benelli A, Cavazzuti E, Bertolini A
Department of Biomedical Sciences, Section of Pharmacology, University of Modena, Italy.
Neuropeptides. 1998 Apr;32(2):151-5. doi: 10.1016/s0143-4179(98)90030-0.
The penile erection-inducing effect of intracerebroventricularly (i.c.v.) injected adrenocorticotropin-(1-24) [ACTH-(1-24)] (4 or 10 microg/animal) was almost completely absent in diabetic rats, either 8 days or 2 months after streptozotocin administration. The other behavioral symptoms (stretching, yawning, excessive grooming) were unevenly affected: stretching was significantly reduced either in early or in long-standing diabetes; yawning was practically absent in early diabetes and significantly reduced at the highest dose of ACTH-(1-24) in long-standing diabetes; grooming was reduced only at the highest dose of ACTH-(1-24), both in early and in long-standing diabetes. The fact that ACTH-induced penile erections (a centrally mediated effect) are practically absent even a few days after streptozotocin injection suggests that diabetes mellitus-induced penile dysfunction occurs, at least in part, through central mechanisms, and is not solely the consequence of peripheral nerve and vascular lesions.
在链脲佐菌素给药8天或2个月后的糖尿病大鼠中，脑室内（i.c.v.）注射促肾上腺皮质激素-（1-24）[ACTH-（1-24）]（4或10微克/只动物）诱导阴茎勃起的作用几乎完全消失。其他行为症状（伸展、打哈欠、过度梳理毛发）受到的影响不均衡：在早期或长期糖尿病中，伸展显著减少；在早期糖尿病中几乎没有打哈欠，在长期糖尿病中，ACTH-（1-24）最高剂量时打哈欠显著减少；在早期和长期糖尿病中，只有在ACTH-（1-24）最高剂量时梳理毛发才减少。即使在链脲佐菌素注射几天后，ACTH诱导的阴茎勃起（一种中枢介导的效应）实际上也不存在，这一事实表明，糖尿病诱导的阴茎功能障碍至少部分是通过中枢机制发生的，而不仅仅是外周神经和血管病变的结果。
