Vergoni A V, Sandrini M, Filaferro M, Bertolini A
Department of Biomedical Sciences, University of Modena, Italy.
Neurosci Lett. 1995 Mar 16;188(1):29-32. doi: 10.1016/0304-3940(95)11387-c.
In adult male rats, the intracerebroventricular (i.c.v.) injection of pinacidil, a potassium channel opener, at the doses of 100, 200 or 300 micrograms/rat, dose-dependently reduced the display of the most typical behavioral symptoms (excessive grooming, stretching, yawning, penile erections) induced by the i.c.v. administration of ACTH-(1-24) (4 micrograms/rat). These data indicate that the complex mechanism of the melanocortin-induced behavioral syndrome involves closure of potassium channels in target neurons, and provide further experimental support to the idea that melanocortins are functional antagonists of opioids.
在成年雄性大鼠中，脑室内（i.c.v.）注射钾通道开放剂吡那地尔，剂量分别为100、200或300微克/只大鼠，可剂量依赖性地减少由脑室内注射促肾上腺皮质激素（ACTH）-（1-24）（4微克/只大鼠）诱导的最典型行为症状（过度梳理毛发、伸展、打哈欠、阴茎勃起）的表现。这些数据表明，黑皮质素诱导的行为综合征的复杂机制涉及靶神经元中钾通道的关闭，并为黑皮质素是阿片类药物的功能性拮抗剂这一观点提供了进一步的实验支持。
