Grond M, Pawlik G, Walter H, Lesch O M, Heiss W D
Max-Planck-Institut für neurologische Forschung, Cologne, Germany.
Psychiatry Res. 1995 Sep 29;61(3):173-9. doi: 10.1016/0925-4927(95)02571-e.
In an attempt to elucidate the physiological basis of hypnosis, we investigated the changes of whole-brain and regional cerebral glucose metabolism, from a state of resting wakefulness to a hypnotized state with whole-body catalepsy, using positron emission tomography and the 2[18F]fluorodeoxyglucose method in 15 highly hypnotizable adults. Neither the random order of study conditions nor any of the other experimental factors had a measurable effect, and there was no statistically significant global activation or metabolic depression. However, repeated measures analysis of variance revealed a statistically significant heterogeneity of symmetric regional responses: Mainly the occipital areas, including visual and paravisual cortex, became relatively deactivated, while some metabolic recruitment was found in structures involved in sensorimotor functions. The observed pattern of changes of regional cerebral activity corresponds with the shift of attention away from normal sensory input that hypnosis is known to produce.
为了阐明催眠的生理基础，我们采用正电子发射断层扫描和2-[18F]氟脱氧葡萄糖法，对15名高度可催眠的成年人从静息觉醒状态到伴有全身僵住症的催眠状态下的全脑和局部脑葡萄糖代谢变化进行了研究。研究条件的随机顺序以及任何其他实验因素均未产生可测量的影响，并且没有统计学上显著的整体激活或代谢抑制。然而，重复测量方差分析显示对称区域反应存在统计学上显著的异质性：主要是枕叶区域，包括视觉和视觉旁皮层，变得相对失活，而在涉及感觉运动功能的结构中发现了一些代谢增强。观察到的局部脑活动变化模式与已知催眠所产生的注意力从正常感觉输入转移相一致。
