Urbain J L, Charkes N D
Department of Diagnostic Imaging, Temple University Hospital, Philadelphia, PA 19140.
Semin Nucl Med. 1995 Oct;25(4):318-25. doi: 10.1016/s0001-2998(95)80005-0.
Gastric emptying scintigraphy was introduced more than 25 years ago by Griffith and still remains the gold standard to assess gastric emptying. Test meals, radiopharmaceutical and acquisition procedures have been refined and optimized over the years and the test procedure is now well standardized. However, in its most common use, gastric emptying scintigraphy provides little information on gastric physiology and pathophysiology. Over the last decade, modeling of the liquid- and solid-emptying curves has provided some insight into the complex gastric physiology. Compartmental analysis of the stomach has also provided information on the pathophysiological mechanisms of delayed gastric emptying. Over the past 5 years, the most dramatic development in gastric emptying scintigraphy has been the introduction of digital antral scintigraphy. Digital antral scintigraphy consists primarily of dynamic imaging of the stomach and a refined Fourier transform processing method. This new procedure allows for the visualization of antral contractions and, like manometry, permits quantitative characterization of the frequency and amplitude of these contractions. Overall, this new procedure provides a unique, noninvasive tool to characterize gastric motility, to define the pathophysiological mechanisms of gastric motor disorders, and to evaluate the effect of new gastrokinetic compounds.
胃排空闪烁扫描术是25多年前由格里菲斯引入的，至今仍是评估胃排空的金标准。多年来，试餐、放射性药物和采集程序都得到了改进和优化，现在测试程序已经得到了很好的标准化。然而，在其最常见的应用中，胃排空闪烁扫描术提供的关于胃生理和病理生理的信息很少。在过去十年中，对液体和固体排空曲线的建模为复杂的胃生理提供了一些见解。胃的房室分析也提供了关于胃排空延迟的病理生理机制的信息。在过去5年中，胃排空闪烁扫描术最显著的发展是数字胃窦闪烁扫描术的引入。数字胃窦闪烁扫描术主要包括胃的动态成像和一种改进的傅里叶变换处理方法。这种新程序可以显示胃窦收缩，并且像测压法一样，可以对这些收缩的频率和幅度进行定量表征。总体而言，这种新程序提供了一种独特的非侵入性工具，用于表征胃动力、确定胃运动障碍的病理生理机制以及评估新型促胃肠动力化合物的效果。
