Pui M H, Tan A P
Department of Radiology, National University of Singapore, Singapore.
Skeletal Radiol. 1995 Oct;24(7):499-503. doi: 10.1007/BF00202145.
Melioidosis is a tropical infection caused by a gram-negative bacillus, Pseudomonas pseudomallei. The disease manifests initially as localized suppurative lesions and can progress to acute disseminated septicemia with 65-90% mortality if inadequately treated. Musculoskeletal involvement is common. The purpose of this study was to describe the clinical features and imaging appearances of musculoskeletal melioidosis.
We retrospectively analyzed the clinical profiles and images of 26 patients diagnosed over a 6-year period as suffering from melioidosis.
The study group comprised 11 patients with musculoskeletal melioidosis and 15 patients with nonmusculoskeletal melioidosis.
We found that musculoskeletal melioidosis mimicks other infections both clinically and radiologically. Clinical awareness is therefore crucial, as diagnosis can only be established by bacteriological and immunological studies. Prompt treatment with long-term combination antibiotics in high dosages and surgical drainage of abscesses improves survival.
类鼻疽是由革兰氏阴性杆菌类鼻疽假单胞菌引起的一种热带感染病。该病最初表现为局部化脓性病变，若治疗不当可发展为急性播散性败血症，死亡率达65% - 90%。骨骼肌肉受累很常见。本研究的目的是描述骨骼肌肉类鼻疽的临床特征和影像学表现。
我们回顾性分析了6年间确诊为类鼻疽的26例患者的临床资料和影像资料。
研究组包括11例骨骼肌肉类鼻疽患者和15例非骨骼肌肉类鼻疽患者。
我们发现骨骼肌肉类鼻疽在临床和放射学上都与其他感染相似。因此，临床意识至关重要，因为只有通过细菌学和免疫学研究才能确诊。及时使用大剂量长期联合抗生素治疗以及对脓肿进行外科引流可提高生存率。
