Gurney J G, Mueller B A, Davis S, Schwartz S M, Stevens R G, Kopecky K J
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Am J Epidemiol. 1996 Jan 15;143(2):120-8. doi: 10.1093/oxfordjournals.aje.a008718.
To assess the relation between childhood brain tumor occurrence and exposure to potential sources of residential magnetic fields, a population-based case-control study of incident brain tumors was conducted in the Seattle, Washington, area at the Fred Hutchinson Cancer Research Center from 1989 to 1994 among children younger than age 20 years who were diagnosed from 1984 to 1990. The specific aims were to evaluate whether proximity to high-current residential power lines, as defined by the Wertheimer-Leeper code, or use of electric appliances or electric heating sources by the mother while pregnant or by the child before diagnosis were associated with increased risks of brain tumor occurrence. The mothers of 133 cases and 270 controls (recruited by random digit dialing) participated. Risk of brain tumor occurrence did not increase with increasing exposure, as indicated by the five-level Wertheimer-Leeper code. When exposure was dichotomized as high versus low, the odds ratio was 0.9 (95% confidence interval 0.5-1.5) and did not vary significantly by sex, age, or histology. No elevations in risk were found for ever versus never use of electric blankets, water beds, or electric heating sources. Odds ratios were slightly elevated for nine appliances and were at or below 1.0 for eight others. These data do not support the hypothesis that exposure to magnetic fields from high-current power lines, electric heating sources, or electric appliances is associated with the subsequent occurrence of brain tumors in children.
为评估儿童脑瘤发生与接触住宅磁场潜在来源之间的关系，1989年至1994年在华盛顿州西雅图市的弗雷德·哈钦森癌症研究中心，针对1984年至1990年期间确诊的20岁以下儿童开展了一项基于人群的新发脑瘤病例对照研究。具体目的是评估按照韦特海默 - 利珀编码定义的靠近高电流住宅电力线情况，或母亲在孕期或孩子在诊断前使用电器或电加热源是否与脑瘤发生风险增加相关。133例病例的母亲和270名对照（通过随机数字拨号招募）参与了研究。如五级韦特海默 - 利珀编码所示，脑瘤发生风险并未随暴露增加而升高。当将暴露分为高暴露与低暴露时，比值比为0.9（95%置信区间0.5 - 1.5），且在性别、年龄或组织学方面无显著差异。对于是否曾经使用电热毯、水床或电加热源，未发现风险升高。九种电器的比值比略有升高，另外八种电器的比值比等于或低于1.0。这些数据不支持如下假设：接触来自高电流电力线、电加热源或电器的磁场与儿童随后发生脑瘤有关。
