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Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene.

作者信息

Puertollano R, Visedo G, Saiz-Ruiz J, Llinares C, Fernández-Piqueras J

机构信息

Departamento de Biología, Universidad Autónoma de Madrid, Spain.

出版信息

Am J Med Genet. 1995 Oct 9;60(5):434-5. doi: 10.1002/ajmg.1320600514.

DOI:10.1002/ajmg.1320600514
PMID:8546157
Abstract

We have carried out an association study between a dinucleotide repeat polymorphism in GABRA3 gene and manic-depressive illness in a Spanish population. This may be an important candidate gene for bipolar affective disorders since it is located in the Xq28 region, previously implicated in linkage studies. In addition, severe GABergic alterations have been reported in patients. We have not found significant differences between controls and patients in allele frequencies or genotypes.

摘要

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