Moises H W, Yang L, Li T, Havsteen B, Fimmers R, Baur M P, Liu X, Gottesman I I
Department of Psychiatry, Kiel University Hospital, Germany.
Am J Med Genet. 1995 Oct 9;60(5):465-7. doi: 10.1002/ajmg.1320600521.
Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pair analysis. In order to replicate these results, we performed the transmission test for linkage disequilibrium (TDT) in 113 unrelated schizophrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of the marker AFM 182xd12 at the locus D22S278 (P = 0.02). The results of our study suggest a detectable oligogenic gene in a multigene system for schizophrenia closely linked to D22S278 on the long arm of chromosome 22. If confirmed by others, this finding could lead to the identification of a schizophrenia susceptibility gene.
通过同胞对分析，位于22q12的基因座D22S278被认为与精神分裂症有关。为了重复这些结果，我们对113名无亲缘关系的精神分裂症患者及其226名父母进行了连锁不平衡传递检验（TDT）。在基因座D22S278处，精神分裂症与标记AFM 182xd12的243等位基因之间获得了潜在连锁不平衡的证据（P = 0.02）。我们的研究结果表明，在一个多基因系统中，存在一个可检测到的与精神分裂症相关的寡基因，它与22号染色体长臂上的D22S278紧密连锁。如果其他人能证实这一发现，可能会导致鉴定出一个精神分裂症易感基因。
