Niwa T, Asada H, Tsutsui S, Miyazaki T
Nagoya University Branch Hospital, Japan.
Am J Nephrol. 1995;15(6):463-7. doi: 10.1159/000168887.
Furancarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF), an inhibitor of erythropoiesis, cannot be removed by conventional hemodialysis due to its strong albumin binding, resulting in its accumulation in uremic serum. We used protein-leaking hemodialysis with BK-F dialyzers in 8 uremic patients for 4 months to determine its effect on the serum levels of CMPF. Pre-hemodialysis serum levels of CMPF significantly decreased to about 50% after 4 months by protein-leaking hemodialysis, while those of BUN and serum creatinine did not change significantly. Pre-hemodialysis hematocrit and hemoglobin levels significantly increased by protein-leaking hemodialysis. These results indicate that protein-leaking hemodialysis reduces serum levels of albumin-bound CMPF and improves anemia.
呋喃羧酸（3-羧基-4-甲基-5-丙基-2-呋喃丙酸，CMPF）是一种红细胞生成抑制剂，由于其与白蛋白的强结合力，常规血液透析无法将其清除，导致其在尿毒症血清中蓄积。我们对8例尿毒症患者使用BK-F透析器进行了4个月的蛋白渗漏血液透析，以确定其对CMPF血清水平的影响。通过蛋白渗漏血液透析，4个月后，透析前CMPF的血清水平显著降低至约50%，而尿素氮和血清肌酐水平无显著变化。蛋白渗漏血液透析使透析前的血细胞比容和血红蛋白水平显著升高。这些结果表明，蛋白渗漏血液透析可降低与白蛋白结合的CMPF的血清水平，并改善贫血。
