Uchida K, Akaza H, Shimazui T, Kikuchi K, Manabe F, Iwasaki A, Ishikawa S, Noguchi R, Otani M, Hattori K, Kondo F, Nishijima Y, Sato K, Koiso K, Hinotsu S
Dept. of Urology, University of Tsukuba.
Gan To Kagaku Ryoho. 1996 Jan;23(1):81-6.
A cross-over clinical trial was carried out to compare the antiemetic effect and safety between granisetron alone (40 micrograms/kg) and the combination of granisetron and methylprednisolone (MP: 10 mg/kg) in urological cancer patients treated with cisplatin. Forty-eight courses were given with granisetron alone and 47 courses with both granisetron and MP. The antiemetic effect of nausea and vomiting was evaluated in the acute emetic phase. during the 24 hours following the CDDP administration, and in the delayed emetic phase, 2 to 7 days after the administration. Combination therapy of granisetron and MP demonstrated a greater antiemetic effect during the 72 hours following the CDDP administration than by granisetron alone. But there was no significant difference in antiemetic effect between combination therapy and granisetron alone after the 3rd day. Combination therapy also demonstrated more efficacy in complete antiemetic effect, with no emesis and less than moderate nausea, than by granisetron alone. Both treatments showed no side effects and were safe.
进行了一项交叉临床试验，以比较在接受顺铂治疗的泌尿生殖系统癌症患者中，单独使用格拉司琼（40微克/千克）与格拉司琼和甲泼尼龙联合使用（甲泼尼龙：10毫克/千克）的止吐效果和安全性。单独使用格拉司琼治疗了48个疗程，格拉司琼与甲泼尼龙联合使用治疗了47个疗程。在顺铂给药后的24小时内的急性呕吐期以及给药后2至7天的延迟呕吐期，对恶心和呕吐的止吐效果进行了评估。格拉司琼与甲泼尼龙联合治疗在顺铂给药后的72小时内显示出比单独使用格拉司琼更大的止吐效果。但在第3天之后，联合治疗与单独使用格拉司琼的止吐效果没有显著差异。联合治疗在完全止吐效果方面也比单独使用格拉司琼更有效，即无呕吐且恶心程度低于中度。两种治疗均未显示出副作用且安全。
