Kurita A, Takashima S, Nakata M, Kubo Y, Saiki T, Ohsumi S, Yokoyama N, Tanada M, Takiyama W, Saeki H
Dept. of Surgery, Shikoku Cancer Center Hospital.
Gan To Kagaku Ryoho. 1997 Jan;24(1):49-54.
CDDP is one of the most effective drugs in chemotherapy for gastric cancer. We compared the antiemetic effect of a combination of granisetron and methylprednisolone with that of granisetron administered alone. Twenty postgastrectomy-patients who were to receive moderately emetogenic chemotherapy, including CDDP, were enrolled in randomized fashion to evaluate the efficacy and toxicity of two antiemetic regimens. The following antiemetic regimens were used: 3 mg of granisetron given intravenously before chemotherapy (11 patients) or a combination of granisetron and 250 mg of methylprednisolone in the same manner (9 patients). Granisetron combined with methylprednisolone tender to be more effective than granisetron alone. The adverse effects were very mild. Their efficacy against delayed emesis is still not entirely satisfactory.
顺铂是胃癌化疗中最有效的药物之一。我们比较了格拉司琼与甲基强的松龙联合用药和单独使用格拉司琼的止吐效果。20例接受包括顺铂在内的中度致吐性化疗的胃切除术后患者被随机纳入研究，以评估两种止吐方案的疗效和毒性。采用了以下止吐方案：化疗前静脉注射3毫克格拉司琼（11例患者）或同样方式使用格拉司琼与250毫克甲基强的松龙联合用药（9例患者）。格拉司琼与甲基强的松龙联合用药往往比单独使用格拉司琼更有效。不良反应非常轻微。它们对延迟性呕吐的疗效仍不完全令人满意。
