Han P, Stacy D, Story C, Owens P C
Department of Haematology, Women's and Children's Hospital, Adelaide, Australia.
Br J Haematol. 1995 Oct;91(2):327-9. doi: 10.1111/j.1365-2141.1995.tb05297.x.
The anaemia of prematurity has been attributed to an insufficient erythropoietin (Epo) level. However, haemopoiesis is known to be regulated by a cohort of growth factors including interleukin-3 (IL-3), IL-6, stem cell factor (SCF), granulocyte monocyte-colony stimulating factor (GM-CSF) and insulin-like growth factors-I and -II (IGF-1, IGF-II). Circulating levels of these growth factors were measured in cord blood at the following gestational ages: 25-28 weeks, 29-32 weeks, 33-36 weeks and > 37 weeks. This study indicates that low concentrations of IGFs as well as a low Epo level in early gestational ages may play a role in anaemia of prematurity.
早产儿贫血被认为与促红细胞生成素（Epo）水平不足有关。然而，已知造血过程受一组生长因子调节，包括白细胞介素-3（IL-3）、IL-6、干细胞因子（SCF）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）以及胰岛素样生长因子-I和-II（IGF-1、IGF-II）。在以下孕周的脐血中测量了这些生长因子的循环水平：25 - 28周、29 - 32周、33 - 36周和>37周。这项研究表明，孕早期低浓度的胰岛素样生长因子以及低Epo水平可能在早产儿贫血中起作用。
