Zappacosta B, De Sole P, Rossi C, Marra G, Ghirlanda G, Giardina B
Instituto di Chimica e Chimica Clinica, Università Cattolica del S. Cuore, Rome, Italy.
Eur J Clin Chem Clin Biochem. 1995 Aug;33(8):487-9.
Lactate dehydrogenase (L-lactate : NAD+ oxidoreductase, EC 1.1.1.27) activity has been measured on the subpopulations of platelets obtained from blood of diabetic patients. Small, but not large platelets show a lactate dehydrogenase activity higher than that of controls. Moreover, a positive statistically significant correlation was found between the activity of small platelets and the percent of glycated haemoglobin, while no correlation was obtained in the case of large platelets. Since we previously demonstrated that lactate dehydrogenase activity of small platelets is exceedingly high in some clinical and experimental conditions, our results not only confirm the involvement of platelets in diabetes but provide more evidence in support of our previous hypothesis of a relationship between lactate dehydrogenase and in-vivo platelet activation.
已对从糖尿病患者血液中获取的血小板亚群测定了乳酸脱氢酶（L-乳酸：NAD⁺氧化还原酶，EC 1.1.1.27）活性。小血小板而非大血小板的乳酸脱氢酶活性高于对照组。此外，小血小板活性与糖化血红蛋白百分比之间存在统计学上的显著正相关，而大血小板则未发现相关性。由于我们之前证明在某些临床和实验条件下小血小板的乳酸脱氢酶活性极高，我们的结果不仅证实了血小板与糖尿病有关，还为支持我们之前关于乳酸脱氢酶与体内血小板活化之间关系的假设提供了更多证据。
