降钙素基因相关肽（CGRP）和胰淀素对肌肉糖原代谢的调节：CGRP受体未参与其中。
Regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved.
作者信息
Beaumont K, Pittner R A, Moore C X, Wolfe-Lopez D, Prickett K S, Young A A, Rink T J
机构信息
Amylin Pharmaceuticals, Inc., San Diego, CA 92121, USA.
出版信息
Br J Pharmacol. 1995 Jul;115(5):713-5. doi: 10.1111/j.1476-5381.1995.tb14991.x.
The aim of the present study was to determine whether amylin and calcitonin gene-related peptide (CGRP) act through shared or distinct receptors to inhibit insulin-stimulated incorporation of [14C]-glucose into glycogen. Rat amylin was 3 fold more potent than either rat alpha CGRP or rat beta CGRP at reducing glycogen synthesis from [14C]-glucose in insulin-treated rat soleus muscle. This action was blocked by peptide antagonists, with the rank order of potency being AC187 > salmon calcitonin8-32 (sCT8-32) > h-alpha CGRP8-37 for antagonism of either amylin or CGRP. The antagonist potency order correlated with affinity for amylin receptors measured in rat nucleus accumbens but not CGRP receptors measured in rat L6 muscle cells. Inhibition of glucose incorporation into glycogen by amylin and CGRP appears to be mediated by shared receptors that have the pharmacological characteristics of amylin receptors, and are distinct from previously described CGRP receptors.
本研究的目的是确定胰岛淀粉样多肽（amylin）和降钙素基因相关肽（CGRP）是否通过共同的或不同的受体来抑制胰岛素刺激的[14C] -葡萄糖掺入糖原。在胰岛素处理的大鼠比目鱼肌中，大鼠胰岛淀粉样多肽在降低[14C] -葡萄糖合成糖原方面的效力比大鼠α-CGRP或大鼠β-CGRP高3倍。这种作用被肽拮抗剂阻断，对于胰岛淀粉样多肽或CGRP拮抗作用的效力顺序为AC187>鲑鱼降钙素8 - 32（sCT8 - 32）>人α-CGRP8 - 37。拮抗剂效力顺序与在大鼠伏隔核中测量的对胰岛淀粉样多肽受体的亲和力相关，但与在大鼠L6肌细胞中测量的CGRP受体的亲和力无关。胰岛淀粉样多肽和CGRP对葡萄糖掺入糖原的抑制作用似乎是由具有胰岛淀粉样多肽受体药理学特征的共同受体介导的，并且与先前描述的CGRP受体不同。
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