西罗莫司（雷帕霉素）可抑制有丝分裂原诱导的原代淋巴细胞中蛋白质合成的刺激作用。 - Suppr

Suppr

超能文献

Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes.

作者信息

Bansbach C C, Wancio D, Sehgal S N

机构信息

Wyeth-Ayerst Research, Princeton, NJ 08543-8000, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S179-80. doi: 10.1007/BF01778320.

DOI:10.1007/BF01778320

PMID:8548386

Abstract

摘要

相似文献

Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes.西罗莫司（雷帕霉素）可抑制有丝分裂原诱导的原代淋巴细胞中蛋白质合成的刺激作用。

Inflamm Res. 1995 Aug;44 Suppl 2:S179-80. doi: 10.1007/BF01778320.

Rapamycin-resistant human lymphoid cell lines.

Biochem Soc Trans. 1996 Feb;24(1):89S. doi: 10.1042/bst024089s.

Mechanism of action of rapamycin (Sirolimus, Rapamune).

Transplant Proc. 1996 Apr;28(2):964-9.

Rapamycin resistance tied to defective regulation of p27Kip1.雷帕霉素抗性与p27Kip1的调节缺陷有关。

Mol Cell Biol. 1996 Dec;16(12):6744-51. doi: 10.1128/MCB.16.12.6744.

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.雷帕霉素抑制核糖体蛋白合成，并在有丝分裂原激活的T淋巴细胞中诱导G1期延长。

J Immunol. 1995 Oct 1;155(7):3418-26.

Effects of the new and highly active immunosuppressant, rapamycin, on lymphoid tissues and cells in vivo.新型高效免疫抑制剂雷帕霉素对体内淋巴组织和细胞的作用。

Transplant Proc. 1991 Feb;23(1 Pt 1):851-5.

Evidence that FK506 and rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and PP2A.有证据表明，FK506和雷帕霉素在相对于涉及蛋白磷酸酶PP1和PP2A的早期可逆磷酸化的不同位点阻断T细胞活化。

Transplantation. 1991 Jun;51(6):1318-20. doi: 10.1097/00007890-199106000-00039.

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells.雷帕霉素抑制白细胞介素-2和丝裂原激活的人T细胞中p70 S6激酶的磷酸化。

Biochem Biophys Res Commun. 1992 Aug 14;186(3):1315-21. doi: 10.1016/s0006-291x(05)81549-9.

The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma.地塞米松、环孢素和雷帕霉素对体外T淋巴细胞增殖的影响：糖皮质激素敏感和糖皮质激素抵抗的慢性哮喘患者细胞的比较

J Allergy Clin Immunol. 1994 Feb;93(2):510-9. doi: 10.1016/0091-6749(94)90361-1.

Comparison of effects of sirolimus on cytokine dependent and cytokine independent proliferation.

Inflamm Res. 1995 Aug;44 Suppl 2:S189-90. doi: 10.1007/BF01778325.

引用本文的文献

Immune profiling and cancer post transplantation.免疫分析与移植后癌症

World J Nephrol. 2015 Feb 6;4(1):41-56. doi: 10.5527/wjn.v4.i1.41.

本文引用的文献

Rapamycin: in vitro profile of a new immunosuppressive macrolide.雷帕霉素：一种新型免疫抑制大环内酯类药物的体外特性

Ann N Y Acad Sci. 1993 Jun 23;685:58-67. doi: 10.1111/j.1749-6632.1993.tb35852.x.

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.雷帕霉素选择性抑制“多嘧啶序列”mRNA家族的翻译。

Proc Natl Acad Sci U S A. 1994 May 10;91(10):4441-5. doi: 10.1073/pnas.91.10.4441.

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.雷帕霉素选择性抑制p70 S6激酶的白细胞介素-2激活。

Nature. 1992 Jul 2;358(6381):70-3. doi: 10.1038/358070a0.

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells.雷帕霉素抑制白细胞介素-2和丝裂原激活的人T细胞中p70 S6激酶的磷酸化。

Biochem Biophys Res Commun. 1992 Aug 14;186(3):1315-21. doi: 10.1016/s0006-291x(05)81549-9.

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.雷帕霉素诱导的70千道尔顿S6蛋白激酶的抑制作用。

Science. 1992 Aug 14;257(5072):973-7. doi: 10.1126/science.1380182.

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.

Cell. 1992 Jun 26;69(7):1227-36. doi: 10.1016/0092-8674(92)90643-q.

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