The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor.

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作者信息

Kimble E, Hadala J, Ludewig R, Peters P, Greenberg G, Xiao G, Guida W, McQuire L, Simon P

机构信息

Research Department, Ciba-Geigy Corp., Summit, NJ 07901, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S181-2. doi: 10.1007/BF01778321.

DOI:10.1007/BF01778321

PMID:8548387

Abstract

摘要

相似文献

The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor.

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本文引用的文献

An enzymic method for the determination of inorganic phosphate in serum.一种测定血清中无机磷酸盐的酶法。

Chem Pharm Bull (Tokyo). 1981 May;29(5):1451-5. doi: 10.1248/cpb.29.1451.

Identification of nucleosides and bases in serum and plasma samples by reverse-phase high performance liquid chromatography.通过反相高效液相色谱法鉴定血清和血浆样本中的核苷和碱基。

Anal Chem. 1977 Dec;49(14):2237-41. doi: 10.1021/ac50022a032.

Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase.嘌呤核苷磷酸化酶缺乏患者的异常嘌呤代谢和嘌呤过度生成。

N Engl J Med. 1976 Dec 23;295(26):1449-54. doi: 10.1056/NEJM197612232952603.

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).腺苷脱氨酶缺乏症和嘌呤核苷磷酸化酶缺乏症中的淋巴细胞特异性毒性：核苷激酶的可能作用。

Proc Natl Acad Sci U S A. 1977 Dec;74(12):5677-81. doi: 10.1073/pnas.74.12.5677.

Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity.一名T细胞免疫严重缺陷而B细胞免疫正常的儿童出现核苷磷酸化酶缺乏症。

Lancet. 1975 May 3;1(7914):1010-3. doi: 10.1016/s0140-6736(75)91950-9.

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