Rossetti L
Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA.
Clin Invest Med. 1995 Aug;18(4):255-60.
Non-insulin-dependent diabetes mellitus (NIDDM) results from a disruption of normal glucose homeostasis, primarily insulin secretion and hepatic and peripheral insulin action. However, chronic hyperglycemia has been shown in animal models to contribute to impaired insulin secretion as well as to peripheral insulin resistance. Consequently, stringent control measures aimed at ameliorating chronically elevated blood glucose levels may help lessen the cellular "toxic" effect of hyperglycemia.
非胰岛素依赖型糖尿病（NIDDM）是由正常葡萄糖稳态的破坏引起的，主要是胰岛素分泌以及肝脏和外周胰岛素作用的破坏。然而，动物模型显示慢性高血糖会导致胰岛素分泌受损以及外周胰岛素抵抗。因此，旨在改善长期升高的血糖水平的严格控制措施可能有助于减轻高血糖的细胞“毒性”作用。
