Niinimäki A
University Hospital, Department of Dermatology, Oulu, Finland.
Contact Dermatitis. 1995 Aug;33(2):78-83. doi: 10.1111/j.1600-0536.1995.tb00505.x.
Patch tests (PTs) with spices, such as clove, cinnamon, Jamaica pepper and vanillin sugar, and with balsam of Peru were made on 29 patients 0.8-2.9 years after an allergy to balsam of Peru had been detected. Positive reactions to balsam of Peru were seen in 17 patients, and to clove, Jamaica pepper or cinnamon in 5. Double-blind placebo-controlled peroral challenges (DBPCPCs) with balsam of Peru and spices (active substances) were performed on 22 patients. A substantial increase (30-280%) in the number of palmar vesicles after the DBPCPC with the active substances, but not with placebo, was seen in 8 patients, an increase with both the active substances and placebo in 3, and with placebo but not the active substances in 1 patient. 4 of the 8 patients with positive DBPCPCs with the active substances were negative to balsam of Peru in the 2nd PT. No other objective symptoms were seen after the DBPCPCs. Balsam of Peru and the spices were retested 3 months after the DBPCPC. Both alleviation and aggravation of the PT reactions were seen. It is concluded that ingested flavoured foods might cause systemic contact reactions in some patients with allergy to balsam of Peru, but the benefits of a flavour-avoiding diet are questionable in all of them.
在检测到对秘鲁香脂过敏后的0.8 - 2.9年，对29名患者进行了香料斑贴试验（PTs），这些香料包括丁香、肉桂、牙买加胡椒和香草糖，以及秘鲁香脂斑贴试验。17名患者对秘鲁香脂呈阳性反应，5名患者对丁香、牙买加胡椒或肉桂呈阳性反应。对22名患者进行了秘鲁香脂和香料（活性物质）的双盲安慰剂对照口服激发试验（DBPCPCs）。8名患者在接受活性物质而非安慰剂的DBPCPC后，手掌水疱数量大幅增加（30% - 280%），3名患者对活性物质和安慰剂均有增加，1名患者对安慰剂有增加但对活性物质无增加。8名对活性物质DBPCPC呈阳性的患者中有4名在第二次PT中对秘鲁香脂呈阴性。DBPCPC后未观察到其他客观症状。在DBPCPC后3个月对秘鲁香脂和香料进行了重新检测。PT反应既有减轻也有加重。结论是，摄入调味食品可能会在一些对秘鲁香脂过敏的患者中引起全身接触反应，但对所有患者而言，避免食用调味食物的益处值得怀疑。
