Freundt K J, Liebaldt G P, Lieberwirth E
Toxicology. 1977 Apr;7(2):141-53. doi: 10.1016/0300-483x(77)90059-2.
Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced histological evidence of slight to severe fatty degeneration of the liver lobules and Kupffer cells. In addition marked pulmonary hyperaemia and alveolar septal distention were noted. Fibrous swelling of the cardiac muscle (with striation) just barely maintained) and hyperaemia remained detectable for as long as 14 h post-exposure, but only occurred at 3000 ppm/8 h. A concentration of 1000 ppm/8 h was required to produce a fall in blood albumin, urea nitrogen, alkaline phosphatase activities and erythrocyte count. The cited concentrations failed to produce prenarcotic symptoms of narcosis (central nervous system (CNS) depression). The LD50 was found to be 6.0 ml/kg i.p. and 1.0 ml/kg p.o. for female rats, and 3.2 ml/kg i;p. for female mice. In some of the rats killed in these experiments the organ changes were found to be identical to those observed after inhalation.
反式-1,2-二氯乙烯（t-DCE）是一种工业溶剂，在小型实验动物研究中被证明具有中等毒性。在成年雌性大鼠中，短暂（8小时）和长期（每周连续5天，每天8小时，持续超过16周）吸入200 ppm（各国目前的阈限值/最高容许浓度）会产生组织学证据，显示肝小叶和库普弗细胞有轻微至严重的脂肪变性。此外，还观察到明显的肺充血和肺泡间隔扩张。心肌纤维性肿胀（伴有条纹）勉强维持，暴露后长达14小时仍可检测到充血，但仅在3000 ppm/8小时时出现。需要1000 ppm/8小时的浓度才能使血液白蛋白、尿素氮、碱性磷酸酶活性和红细胞计数下降。上述浓度未产生麻醉前的麻醉症状（中枢神经系统抑制）。雌性大鼠的经腹腔注射半数致死量为6.0毫升/千克，经口半数致死量为1.0毫升/千克，雌性小鼠的经腹腔注射半数致死量为3.2毫升/千克。在这些实验中处死的一些大鼠中，发现器官变化与吸入后观察到的变化相同。
