李斯特菌溶血素是人类内皮细胞中磷脂酰肌醇反应和脂质介质生成的有效诱导剂。
Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.
作者信息
Sibelius U, Rose F, Chakraborty T, Darji A, Wehland J, Weiss S, Seeger W, Grimminger F
机构信息
Department of Internal Medicine, Justus Liebig University, Giessen, Federal Republic of Germany.
出版信息
Infect Immun. 1996 Feb;64(2):674-6. doi: 10.1128/iai.64.2.674-676.1996.
Abstract
The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is linked to production of LLO.
摘要
在人脐静脉内皮细胞中研究了单核细胞增生李斯特菌溶血素O（LLO）分泌对磷酸肌醇代谢和介质（血小板活化因子和前列腺素I2）生成的影响。野生型单核细胞增生李斯特菌、纯化的LLO以及经基因工程改造以分泌LLO的无害李斯特菌菌株均引发了强烈反应，而LLO产生缺陷的突变菌株则无效。因此，李斯特菌对人脐静脉内皮细胞的刺激与LLO的产生有关。
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