III型B族链球菌多糖-破伤风类毒素疫苗在狒狒中的免疫原性。
Immunogenicity of group B Streptococcus type III polysaccharide-tetanus toxoid vaccine in baboons.
作者信息
Paoletti L C, Kennedy R C, Chanh T C, Kasper D L
机构信息
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Infect Immun. 1996 Feb;64(2):677-9. doi: 10.1128/iai.64.2.677-679.1996.
Abstract
Maternal vaccination has been proposed as a rational approach for the prevention of neonatal group B streptococcal (GBS) disease. In this study, baboons were used as a nonhuman primate model to evaluate the immunogenicity of a GBS type III glycoconjugate vaccine. Type III-specific immunoglobulin G with opsonic activity was induced after vaccination with type III polysaccharide coupled to tetanus toxoid administered with an aluminum adjuvant. This suggests that baboons could be used in evaluating maternal transfer of GBS-specific antibodies by vaccination during pregnancy.
摘要
母体接种疫苗已被提议作为预防新生儿B族链球菌（GBS）疾病的合理方法。在本研究中，狒狒被用作非人类灵长类动物模型，以评估III型GBS糖共轭疫苗的免疫原性。接种与破伤风类毒素偶联的III型多糖并添加铝佐剂后，诱导产生了具有调理活性的III型特异性免疫球蛋白G。这表明狒狒可用于评估孕期接种疫苗后GBS特异性抗体的母体转移情况。
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