Massad E, Azevedo-Neto R S, Burattini M N, Zanetta D M, Coutinho F A, Yang H M, Moraes J C, Pannuti C S, Souza V A, Silveira A S
Faculdade de Medicina da Universidade de São Paulo, Brazil.
Int J Epidemiol. 1995 Aug;24(4):842-50. doi: 10.1093/ije/24.4.842.
In 1992 a major vaccination strategy against measles-mumps-rubella was introduced in the State of Saão Paulo, Brazil. This strategy was based on mathematical models and comprised a pulse vaccination covering all children aged 1-10 years, followed by the inclusion of this vaccine in the routine calendar at 15 months of age. The present work reports the evaluation of the efficacy of this mixed vaccination strategy.
A rubella seroprevalence survey was carried out immediately and one year after the campaign, comprising 4953 children aged 1-15 years.
We show that average rubella seroprevalence increased from 0.40 to 0.97 and that the reported number of congenital rubella syndrome (CRS) cases dropped dramatically.
The mixed vaccination strategy adopted against rubella has proved to be very effective in reducing the number of CRS cases in São Paulo.
1992年，巴西圣保罗州推出了一项针对麻疹-腮腺炎-风疹的主要疫苗接种策略。该策略基于数学模型，包括对所有1至10岁儿童进行脉冲式疫苗接种，随后将该疫苗纳入15个月龄的常规接种计划。本研究报告了对这种联合疫苗接种策略效果的评估。
在活动结束后立即和一年后进行了一项风疹血清流行率调查，调查对象为4953名1至15岁的儿童。
我们发现风疹平均血清流行率从0.40升至0.97，报告的先天性风疹综合征（CRS）病例数大幅下降。
事实证明，所采用的针对风疹的联合疫苗接种策略在减少圣保罗州CRS病例数方面非常有效。
