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J Bacteriol. 1996 Feb;178(3):899-901. doi: 10.1128/jb.178.3.899-901.1996.
2
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本文引用的文献

1
Flagellar growth in a filament-less Salmonella fliD mutant supplemented with purified hook-associated protein 2.在补充有纯化的钩相关蛋白2的无鞭毛丝状体沙门氏菌fliD突变体中的鞭毛生长。
J Biochem. 1993 Jul;114(1):39-44. doi: 10.1093/oxfordjournals.jbchem.a124136.
2
Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator.通过输出负调控因子来感知细菌鞭毛组装中的结构中间体。
Science. 1993 Nov 19;262(5137):1277-80. doi: 10.1126/science.8235660.
3
Role of the FliA-FlgM regulatory system on the transcriptional control of the flagellar regulon and flagellar formation in Salmonella typhimurium.FliA-FlgM调控系统对鼠伤寒沙门氏菌鞭毛操纵子转录控制及鞭毛形成的作用
J Bacteriol. 1994 Jun;176(12):3598-605. doi: 10.1128/jb.176.12.3598-3605.1994.
4
Excretion of the anti-sigma factor through a flagellar substructure couples flagellar gene expression with flagellar assembly in Salmonella typhimurium.通过鞭毛亚结构排出抗σ因子，使鼠伤寒沙门氏菌中的鞭毛基因表达与鞭毛组装相偶联。
Mol Gen Genet. 1994 Jun 15;243(6):605-12. doi: 10.1007/BF00279569.
5
Isolation and characterization of FliK-independent flagellation mutants from Salmonella typhimurium.鼠伤寒沙门氏菌中弗利克（FliK）非依赖性鞭毛形成突变体的分离与鉴定
J Bacteriol. 1994 Dec;176(24):7625-9. doi: 10.1128/jb.176.24.7625-7629.1994.
6
The FlhD/FlhC complex, a transcriptional activator of the Escherichia coli flagellar class II operons.FlhD/FlhC复合物，大肠杆菌鞭毛II类操纵子的转录激活因子。
J Bacteriol. 1994 Dec;176(23):7345-51. doi: 10.1128/jb.176.23.7345-7351.1994.
7
Transcriptional analysis of the flgK and fliD operons of Salmonella typhimurium which encode flagellar hook-associated proteins.鼠伤寒沙门氏菌鞭毛钩相关蛋白编码基因flgK和fliD操纵子的转录分析。
Mol Gen Genet. 1995 May 10;247(3):275-81. doi: 10.1007/BF00293195.
8
Transcription from two promoters and autoregulation contribute to the control of expression of the Salmonella typhimurium flagellar regulatory gene flgM.来自两个启动子的转录及自身调控有助于控制鼠伤寒沙门氏菌鞭毛调控基因flgM的表达。
J Bacteriol. 1993 Nov;175(21):7006-15. doi: 10.1128/jb.175.21.7006-7015.1993.
9
Functional analysis of the flagellar genes in the fliD operon of Salmonella typhimurium.鼠伤寒沙门氏菌fliD操纵子中鞭毛基因的功能分析。
Microbiology (Reading). 1995 Jul;141 ( Pt 7):1715-22. doi: 10.1099/13500872-141-7-1715.
10
Excretion of unassembled flagellin by Salmonella typhimurium mutants deficient in hook-associated proteins.鼠伤寒沙门氏菌中缺乏钩相关蛋白的突变体对未组装鞭毛蛋白的排泄
J Bacteriol. 1984 Sep;159(3):1056-9. doi: 10.1128/jb.159.3.1056-1059.1984.

鼠伤寒沙门氏菌中鞭毛特异性抗σ因子FlgM输出的fliD、fliS和fliT负调控

Negative regulation by fliD, fliS, and fliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium.

作者信息

Yokoseki T, Iino T, Kutsukake K

机构信息

Faculty of Applied Biological Science, Hiroshima University, Japan.

出版信息

J Bacteriol. 1996 Feb;178(3):899-901. doi: 10.1128/jb.178.3.899-901.1996.

DOI:10.1128/jb.178.3.899-901.1996
PMID:8550529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177741/
Abstract

The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum-specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.

摘要

鼠伤寒沙门氏菌的fliD操纵子由三个鞭毛基因fliD、fliS和fliT组成，并按此顺序转录。研究表明，fliD::Tn10突变会导致鞭毛特异性抗σ因子FlgM过度输出，从而导致鞭毛3类操纵子的过表达。在本研究中，我们利用fliD操纵子中各个基因的基因破坏突变体，证明操纵子中任何一个基因的突变都会增强FlgM的输出和鞭毛调节子的表达。这表明操纵子中的所有三个基因都参与了FlgM输出的负调控。