Binney A, Addy M, Owens J, Faulkner J
Division of Restorative Dentistry, Dental School Bristol, England.
J Clin Periodontol. 1997 Mar;24(3):166-70. doi: 10.1111/j.1600-051x.1997.tb00486.x.
Some triclosan and stannous fluoride toothpastes have been shown effective in reducing plaque and more particularly gingivitis in home use studies. There have been few comparisons of such products for their chemical plaque inhibitory action divorced from the indeterminate variable of toothbrushing. This study was a randomised, single-blind, cross-over comparison of 4 products, in a 4-day plaque regrowth design, balanced for residual effects and involving 12 healthy dentate subjects. The test agents were a stannous fluoride toothpaste, a triclosan/copolymer toothpaste, a triclosan/zinc citrate toothpaste and water. On day 1 of each study period, subjects were rendered plaque free. For the following 4 days, each subject suspended normal toothcleaning and rinsed 2 x daily with the allocated treatment for 60 s under supervision. On day 5, plaque was scored by index. Washout periods of 2 1/2 days brushing with water alone, followed each treatment period. Pseudo treatment periods of 4 days, involving 2 x daily rinsing with water in the absence of toothbrushing, followed the normal washouts after the stannous fluoride and triclosan/zinc citrate treatments, giving a total of 6 treatment periods. This design permitted analyses for 1st-order-carry-over. Intention to treat analyses revealed all toothpastes were more effective than water but that there were no differences between the active treatments. Per protocol analysis gave essentially similar findings except that the difference in plaque in favour of the triclosan/zinc citrate toothpaste over water did not reach significance. There was no evidence of 1st-order-carry-over effects for the stannous fluoride or triclosan/zinc citrate toothpastes. Consistent with other studies it appears that stannous fluoride and triclosan can be formulated into toothpaste vehicles to provide plaque inhibitory effects.
一些含三氯生和氟化亚锡的牙膏在家庭使用研究中已被证明能有效减少牙菌斑，尤其是牙龈炎。对于此类产品在脱离刷牙这一不确定变量后的化学性牙菌斑抑制作用，鲜有比较研究。本研究采用4天牙菌斑再生长设计，对4种产品进行随机、单盲、交叉比较，平衡了残留效应，纳入了12名健康有牙受试者。测试剂分别为一种氟化亚锡牙膏、一种三氯生/共聚物牙膏、一种三氯生/柠檬酸锌牙膏和水。在每个研究周期的第1天，使受试者牙菌斑清除。在接下来的4天里，每位受试者暂停正常牙齿清洁，在监督下每天用分配的处理剂漱口2次，每次60秒。在第5天，通过指数对牙菌斑进行评分。每个处理周期后有2.5天仅用水刷牙的洗脱期。在氟化亚锡和三氯生/柠檬酸锌处理后的正常洗脱期后，有4天的假处理期，即在不刷牙的情况下每天用水漱口2次，共6个处理周期。这种设计允许进行一级残留效应分析。意向性分析显示，所有牙膏都比水更有效，但活性处理之间没有差异。符合方案分析得出的结果基本相似，只是三氯生/柠檬酸锌牙膏相对于水在牙菌斑方面的优势未达到显著水平。没有证据表明氟化亚锡或三氯生/柠檬酸锌牙膏存在一级残留效应。与其他研究一致，似乎氟化亚锡和三氯生可以配制成牙膏载体以提供牙菌斑抑制作用。
