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来自年轻非肥胖糖尿病（NOD）胰岛的CD8 T细胞克隆能够在没有CD4细胞的情况下，使NOD小鼠迅速发生糖尿病。

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

作者信息

Wong F S, Visintin I, Wen L, Flavell R A, Janeway C A

机构信息

Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

出版信息

J Exp Med. 1996 Jan 1;183(1):67-76. doi: 10.1084/jem.183.1.67.

DOI:10.1084/jem.183.1.67
PMID:8551245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192404/
Abstract

T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.

摘要

T细胞在非肥胖糖尿病（NOD）小鼠糖尿病发病机制中起重要作用。从年轻（7周龄）NOD小鼠胰岛的淋巴细胞浸润中，通过在（NOD×B6-RIP-B7-1）F1胰岛上培养，产生了CD8细胞毒性T细胞系和克隆。这些细胞在体外可特异性增殖至NOD胰岛并杀伤NOD胰岛。这些细胞受H-2Kd限制，均携带由Vβ6编码的T细胞抗原受体。当将这些CD8 T细胞系和克隆过继转移至经辐照的雌性NOD、年轻NOD-SCID和CB17-SCID小鼠时，糖尿病在转移后10天内迅速发生，且无需CD4 T细胞。

相似文献

1
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.来自年轻非肥胖糖尿病（NOD）胰岛的CD8 T细胞克隆能够在没有CD4细胞的情况下，使NOD小鼠迅速发生糖尿病。
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2
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本文引用的文献

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Constructing polycompetitor cDNAs for quantitative PCR.构建用于定量PCR的多竞争型cDNA
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Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.β2-微球蛋白缺陷的非肥胖糖尿病（NOD）小鼠不会发生胰岛炎或糖尿病。
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MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region.非肥胖糖尿病（NOD）小鼠的主要组织相容性复合体（MHC）连锁致糖尿病基因：致糖尿病区域3'边界的分子定位
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Evidence for a preferential V beta usage by the T cells which adoptively transfer diabetes in NOD mice.在非肥胖糖尿病（NOD）小鼠中，过继转移糖尿病的T细胞优先使用Vβ的证据。
Eur J Immunol. 1993 Mar;23(3):727-33. doi: 10.1002/eji.1830230324.
10
Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors.将糖尿病移植到免疫缺陷的NOD-scid/scid小鼠体内。来自糖尿病与糖尿病前期NOD.NON-Thy-1a供体的CD4+和CD8+ T细胞的相对贡献。
Diabetes. 1993 Jan;42(1):44-55. doi: 10.2337/diab.42.1.44.