来自年轻非肥胖糖尿病（NOD）胰岛的CD8 T细胞克隆能够在没有CD4细胞的情况下，使NOD小鼠迅速发生糖尿病。
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
作者信息
Wong F S, Visintin I, Wen L, Flavell R A, Janeway C A
机构信息
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
J Exp Med. 1996 Jan 1;183(1):67-76. doi: 10.1084/jem.183.1.67.
Abstract
T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.
摘要
T细胞在非肥胖糖尿病（NOD）小鼠糖尿病发病机制中起重要作用。从年轻（7周龄）NOD小鼠胰岛的淋巴细胞浸润中，通过在（NOD×B6-RIP-B7-1）F1胰岛上培养，产生了CD8细胞毒性T细胞系和克隆。这些细胞在体外可特异性增殖至NOD胰岛并杀伤NOD胰岛。这些细胞受H-2Kd限制，均携带由Vβ6编码的T细胞抗原受体。当将这些CD8 T细胞系和克隆过继转移至经辐照的雌性NOD、年轻NOD-SCID和CB17-SCID小鼠时，糖尿病在转移后10天内迅速发生，且无需CD4 T细胞。
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