Canavero S, Bonicalzi V, Pagni C A, Castellano G, Merante R, Gentile S, Bradac G B, Bergui M, Benna P, Vighetti S
Institute of Neurosurgery, Ospedale Molinette, University of Turin, Italy.
J Neurol. 1995 Sep;242(9):561-7. doi: 10.1007/BF00868808.
Propofol, an intravenous general anaesthetic, has been reported to relieve some forms of pruritus at subhypnotic doses. We assessed its effectiveness in 32 patients with several kinds of non-malignant chronic pain, in a placebo-controlled, double-blind study. We found that central pain, but not neuropathic pain, is at least partially controlled by propofol at subhypnotic doses, without major side-effects. In particular, allodynia associated with central, but no neuropathic, pain has been completely controlled. Propofol analgesia leads to renormalization of brain metabolism as seen on single photon emission computed tomography. We conclude that propofol may help in the diagnosis of central pain, particularly in unclear cases, and also in treatment. Possible mechanisms of action are discussed.
丙泊酚是一种静脉全身麻醉剂，据报道在亚催眠剂量下可缓解某些形式的瘙痒。在一项安慰剂对照、双盲研究中，我们评估了其对32例患有多种非恶性慢性疼痛患者的有效性。我们发现，亚催眠剂量的丙泊酚至少可部分控制中枢性疼痛，但对神经性疼痛无效，且无严重副作用。特别是，与中枢性疼痛而非神经性疼痛相关的异常性疼痛已得到完全控制。单光子发射计算机断层扫描显示，丙泊酚镇痛可使脑代谢恢复正常。我们得出结论，丙泊酚可能有助于中枢性疼痛的诊断，尤其是在情况不明的病例中，也有助于治疗。文中还讨论了可能的作用机制。
