Canavero S, Pagni C A, Castellano G, Bonicalzi V, Belló M, Duca S, Podio V
Institute of Neurosurgery, Ospedale Molinette, University of Turin, Italy.
Neurosurgery. 1993 Feb;32(2):185-9; discussion 190-1. doi: 10.1227/00006123-199302000-00006.
The role of the somatosensory cortex in central pain syndromes is widely questioned. Two recent position emission tomography studies detected a strong activation of the parietal and cingular cortices after brief nociceptive stimuli. On the other hand, a recent single photon emission computed tomography study found no cortical activation in five patients affected by central poststroke pain and algodystrophia. In this study, we present the single photon emission computed tomography findings in five patients suffering from central pain syndromes. Two of these, one with facial postrhizotomy anesthesia dolorosa and the other with central poststroke pain, showed a decrease of blood flow in the parietal lobe, further decreasing after stimulation by nonpainful maneuvers. Our results suggest that somatosensory cortical areas might be involved in the generation of anomalous pain states in some cases of central pain syndromes.
体感皮层在中枢性疼痛综合征中的作用受到广泛质疑。最近两项正电子发射断层扫描研究发现，在短暂的伤害性刺激后，顶叶和扣带回皮层有强烈激活。另一方面，最近一项单光子发射计算机断层扫描研究发现，五名患有中风后中枢性疼痛和营养障碍性疼痛的患者未出现皮层激活。在本研究中，我们展示了五名患有中枢性疼痛综合征患者的单光子发射计算机断层扫描结果。其中两名患者，一名患有面部神经根切断术后麻醉性疼痛，另一名患有中风后中枢性疼痛，其顶叶血流减少，在非疼痛性操作刺激后进一步减少。我们的结果表明，在某些中枢性疼痛综合征病例中，体感皮层区域可能参与了异常疼痛状态的产生。
