Filiberti R, Kubík A, Reissigová J, Merlo F, Bonassi S
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Neoplasma. 1995;42(5):275-83.
A descriptive study aimed at comparing mortality and dietary patterns in Italy and the Czech Republic was conducted in the period 1970-1990. Mortality from all causes, all cancers, selected site specific cancers and cardiovascular diseases were found to be generally higher in the Czech Republic than in Italy. The North-South gradients observed within Italy have diminished in the course of the last twenty years, mostly due to a less contained decrease of the mortality from cardiovascular diseases and to a marked increase in cancer mortality for Southern regions compared to Central and Northern regions. The mediterranean diet with many health promoting, possibly protective components, mostly of vegetable origin, is consumed in most parts of Italy, particularly in the South. In contrast, a Central European diet abounding in animal products and lacking in fresh fruit and vegetables is generally followed in the Czech Republic. These differences in diet may play a role in the origin of the observed differences in mortality patterns. Some factors other than diet, such as smoking habits, alcohol consumption, endogenous factors, and occupation, that are not considered here, are known to be involved in the causation of some types of cancer. The results of this study are compatible with the hypothesis of a relevant role played by dietary and other life-style habits in the etiopathogenesis of neoplastic and cardiovascular diseases.
1970年至1990年期间,开展了一项描述性研究,旨在比较意大利和捷克共和国的死亡率及饮食模式。结果发现,捷克共和国所有原因、所有癌症、特定部位癌症和心血管疾病的死亡率总体上高于意大利。在过去二十年中,意大利境内观察到的南北梯度差异有所减小,这主要是由于心血管疾病死亡率下降幅度较小,以及南部地区癌症死亡率相比中部和北部地区显著上升。意大利大部分地区,尤其是南部,食用的是地中海饮食,这种饮食含有许多促进健康、可能具有保护作用的成分,大多源自蔬菜。相比之下,捷克共和国普遍遵循中欧饮食模式,这种饮食富含动物产品,缺乏新鲜水果和蔬菜。饮食方面的这些差异可能在观察到的死亡率模式差异的成因中发挥作用。除饮食外,一些未在此考虑的因素,如吸烟习惯、酒精消费、内在因素和职业,已知与某些类型癌症的病因有关。本研究结果与饮食及其他生活方式习惯在肿瘤和心血管疾病病因发病机制中发挥重要作用这一假设相符。